(2-Fluorophenyl)phosphane | 647031-47-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-Fluorophenyl)phosphane
• CAS: 647031-47-8
• 化学式: C₆H₆FP
• 分子量: 128.08
• InChiKey: MGJUWNNLIIIAFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• METHOD FOR PREPARING AROMATIC AMINO ACID DERIVATIVE
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP3939962A1

  公开（公告）日：2022-01-19

  The present invention provides methods of efficiently producing various optically active aromatic amino acid derivatives by reacting, using an additive, a specific ester compound with an aromatic halide and zinc in the presence of a catalyst. The present invention also provides amino acid derivatives that can be produced by the methods.

  本发明提供了在催化剂存在下，使用添加剂使特定酯化合物与芳香族卤化物和锌反应，从而高效生产各种光学活性芳香族氨基酸衍生物的方法。本发明还提供了可通过上述方法生产的氨基酸衍生物。
• SEPARATION OF REACTION PRODUCTS CONTAINING ORGANOPHOSPHORUS COMPLEXES
  申请人：UNION CARBIDE COATINGSSERVICE TECHNOLOGY CORP.

  公开号：EP1265831A2

  公开（公告）日：2002-12-18
• CGRP RECEPTOR ANTAGONISTS
  申请人：Merck & Co., Inc.

  公开号：EP1802637B1

  公开（公告）日：2008-10-15
• [EN] IMPROVED SEPARATION PROCESSES<br/>[FR] PROCEDES DE SEPARATION AMELIORES
  申请人：UNION CARBIDE CHEM PLASTIC

  公开号：WO2001068250A2

  公开（公告）日：2001-09-20

  This invention relates to a process for separating one or more organophosphorus ligand degradation products, one or more reaction byproducts and one or more products from a continuously generated reaction product fluid comprising one or more unreacted reactants, a metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, said one or more organophosphorus ligand degradation products, said one or more reaction byproducts, said one or more products, one or more nonpolar solvents and one or more polar solvents by phase separation wherein (i) the selectivity of the nonpolar phase for the organophosphorus ligand with respect to the one or more products is expressed by a partition coefficient ratio Ef1 which is a value greater than about 2.5, (ii) the selectivity of the nonpolar phase for the organophosphorus ligand with respect to the one or more organosphosphorus ligand degradation products is expressed by a partition coefficient ratio Ef2 which is a value greater than about 2.5, and (iii) the selectivity of the nonpolar phase for the organophosphorus ligand with respect to the one or more reaction byproducts is expressed by a partition coefficient ratio Ef3 which is a value greater than about 2.5.
• [EN] IMPROVED SEPARATION PROCESSES<br/>[FR] PROCESSUS DE SEPARATION AMELIORE
  申请人：UNION CARBIDE CHEM PLASTIC

  公开号：WO2001068251A2

  公开（公告）日：2001-09-20

  This invention relates to a process for separating one or more products from a reaction product fluid comprising a metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, said one or more products, one or more nonpolar reaction solvents and one or more polar reaction solvents, wherein said process comprises (1) subjecting said reaction product fluid to fractional countercurrent extraction with at least two immiscible extraction solvents, said at least two immiscible extraction solvents comprising at least one nonpolar extraction solvent and at least one polar extraction solvent, to obtain a nonpolar phase comprising said metal-organophosphorus ligand complex catalyst, said optionally free organophosphorus ligand, said one or more nonpolar reaction solvents and said at least one nonpolar extraction solvent and a polar phase comprising said one or more products, said one or more polar reaction solvents and said at least one polar extraction solvent, and (2) recovering said polar phase from said nonpolar phase; wherein (i) the organophosphorus ligand has a partition coefficient Kp1 defined herein between the nonpolar phase and the polar phase of greater than about 5, and (ii) the one or more products have a partition coefficient Kp2 defined herein between the nonpolar phase and the polar phase of less than about 2.0.