4-[[Cyclopropylmethyl(propyl)amino]methyl]phenol | 864418-19-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[[Cyclopropylmethyl(propyl)amino]methyl]phenol
• CAS: 864418-19-9
• 化学式: C₁₄H₂₁NO
• 分子量: 219.32
• InChiKey: HMGFMKLILBVQHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] THIAZOLOPYRIDIN-2-YLOXY-PHENYL AND THIAZOLOPYRAZIN-2-YLOXY-PHENYL AMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE<br/>[FR] AMINES DE THIAZOLOPYRIDIN-2-YLOXY-PHENYL ET DE THIAZOLOPYRAZIN-2-YLOXY-PHENYL EN TANT QUE MODULATEURS DE LEUKOTRIENE A4 HYDROLASE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2009126806A2

  公开（公告）日：2009-10-15

  Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.