O-pyridin-3-yl-hydroxylamine | 889668-98-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: O-pyridin-3-yl-hydroxylamine
• 英文别名: O-(pyridin-3-yl)hydroxylamine；O-pyridin-3-ylhydroxylamine
• CAS: 889668-98-8
• 化学式: C₅H₆N₂O
• 分子量: 110.115
• InChiKey: GBEIYTQZOLNQTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  48.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  O-pyridin-3-yl-hydroxylamine 、 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 0.25h， 生成
  参考文献：
  名称：

  Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: Length optimization and zero carbon linker oximes

  摘要：

  We designed and synthesized a series of novel 3,6-bicyclolide oximes, possessing linkers of varying lengths to the secondary binding site. The E isomers exhibited excellent antibacterial profiles against a broad spectrum of resistant pathogens. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.07.118
• 作为产物：
  描述：

  2-(Pyridin-3-yloxy)isoindoline-1,3-dione 在 氨 作用下， 以 甲醇 为溶剂， 生成 O-pyridin-3-yl-hydroxylamine
  参考文献：
  名称：

  Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: Length optimization and zero carbon linker oximes

  摘要：

  We designed and synthesized a series of novel 3,6-bicyclolide oximes, possessing linkers of varying lengths to the secondary binding site. The E isomers exhibited excellent antibacterial profiles against a broad spectrum of resistant pathogens. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.07.118

文献信息

• Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: Length optimization and zero carbon linker oximes
  作者：Datong Tang、Yonghua Gai、Alexander Polemeropoulos、Zhigang Chen、Zhe Wang、Yat Sun Or

  DOI：10.1016/j.bmcl.2008.07.118

  日期：2008.9

  We designed and synthesized a series of novel 3,6-bicyclolide oximes, possessing linkers of varying lengths to the secondary binding site. The E isomers exhibited excellent antibacterial profiles against a broad spectrum of resistant pathogens. (C) 2008 Elsevier Ltd. All rights reserved.