2-Aminobutan-1-ol--hydrogen chloride (1/1) | 40916-56-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Aminobutan-1-ol--hydrogen chloride (1/1)
• 英文别名: (2R)-2-aminobutan-1-ol;hydrochloride
• CAS: 40916-56-1
• 化学式: C₄H₁₁NO*ClH
• 分子量: 125.598
• InChiKey: ORIVIUGYHFJFPH-PGMHMLKASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.14
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Aminobutan-1-ol--hydrogen chloride (1/1) 、 苯甲醇 在 叔丁基过氧化氢 、 calcium carbonate 作用下， 以 水 、 乙腈 为溶剂， 反应 6.0h， 以73%的产率得到(R)-N-(1-hydroxybutan-2-yl)benzamide
  参考文献：
  名称：

  超顺磁性Fe（OH）3 @Fe 3 O 4纳米颗粒：一种高效的可回收的胺盐酸盐盐对醇进行串联氧化酰胺化的催化剂

  摘要：

  磁性Fe（OH）3 @Fe 3 O 4纳米粒子的制备和表征成功。该磁性纳米复合材料用作将醇与胺盐酸盐直接酰胺化的有效，可重复使用且对环境无害的多相催化剂。在该催化体系的存在下，以中等至良好的产率合成了伯，仲和叔酰胺的几种衍生物。该催化剂已成功回收利用，最多可重复使用六次，而不会显着降低其催化活性。

  DOI：

  10.1021/co5001844

文献信息

• Green synthesis of primary, secondary, and tertiary amides through oxidative amidation of methyl groups with amine hydrochlorides over recyclable CoFe₂O₄ NPs
  作者：Esmaiel Eidi、Mohammad Zaman Kassaee

  DOI：10.1039/c6ra20902e

  日期：——

  practical and efficient method is developed for efficient synthesis of a wide variety of 1°, 2°, and 3° amides through amidation of methylarenes with amine hydrochloride salts, over magnetic CoFe2O4 NPs as a recyclable nanocatalyst, and aqueous tert-butyl hydroperoxide as an oxidant. This economically sound amidation reaction is operationally straightforward and provides desired amides in good to excellent

  开发了一种实用而有效的方法，通过在磁性CoFe 2 O 4 NPs上作为可循环利用的纳米催化剂和甲基叔丁基胺与盐酸胺盐酸盐进行酰胺化，来高效合成各种1°，2°和3°酰胺。丁基过氧化氢作为氧化剂。这种经济上合理的酰胺化反应操作简便，在温和的条件下，可以以良好或优异的收率提供所需的酰胺。
• Oxidative amidation of aromatic aldehydes with amine hydrochloride salts catalyzed by silica-coated magnetic carbon nanotubes (MagCNTs@SiO₂ )-immobilized imine-Cu(I)
  作者：Dariush Saberi、Akbar Heydari

  DOI：10.1002/aoc.3087

  日期：2014.2

  functionalization, followed by reaction with CuI, were carried out to develop a Cu‐grafted functionalized mesoporous material. This system is able to catalyze oxidative amidation of aromatic aldehydes with amine hydrochloride salts, generating amide derivatives in moderate to good yields. Magnetic properties of this catalyst led to easy separation as well as providing significant recyclability. Copyright

  制备了介孔二氧化硅包覆的磁性碳纳米管。他们进行了表面官能化，然后与CuI反应，以开发出Cu接枝的官能化介孔材料。该系统能够用胺盐酸盐催化芳香醛的氧化酰胺化反应，以中等至良好的产率生成酰胺衍生物。该催化剂的磁性使其易于分离，并具有显着的可回收性。版权所有©2013 John Wiley＆Sons，Ltd.
• 吡咯酰胺类化合物及其制备方法和用途
  申请人：成都微芯药业有限公司

  公开号：CN116768776A

  公开（公告）日：2023-09-19

  本发明涉及一种吡咯酰胺类化合物、其制备方法及其应用。所述化合物的结构如式(I)所示。所述化合物是一类全新的抗HBV化合物。本发明还涉及包含所述化合物作为活性成分的药物组合物，其可用于治疗和/或预防HBV感染，具有重要的应用价值。#imgabs0#
• Direct oxidative amidation of benzyl alcohols using EDTA@Cu(II) functionalized superparamagnetic nanoparticles
  作者：Kobra Azizi、Meghdad Karimi、Fatemeh Nikbakht、Akbar Heydari

  DOI：10.1016/j.apcata.2014.06.009

  日期：2014.7
• Stereo- and Regioselective Synthesis of Polysubstituted Chiral 1,4-Oxazepanes
  作者：Michelle Bezanson、Joshua Pottel、Rana Bilbeisi、Sylvestre Toumieux、Mickaël Cueto、Nicolas Moitessier

  DOI：10.1021/jo3021715

  日期：2013.2.1

  The number of cyclic molecular scaffolds available to medicinal chemists remains limited, and simple structures such as oxazepanes are still made using multistep procedures, including a number of protection/deprotection steps and purifications. We report herein an expedient and efficient synthesis of chiral polysubstituted oxazepanes. The developed method relies on a regio- and stereoselective 7-endo cyclization through haloetherification. Mechanistic studies using a combination of computations and experiments confirmed the expected role of the asymmetry of the chiral bromonium intermediate on the haloetherification regioselectivity. Computations also suggested that the bromonium intermediate is formed with no transition state; hence, the stereoselectivity is controlled primarily by the conformation of the substrate. Applied to a set of 16 substrates, tetra- and pentasubstituted oxazepanes were prepared with good yields and moderate to excellent regio- and stereoselectivities.