N-(1-isopropyl-4-piperidinyl)-N'-phenylurea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(1-isopropyl-4-piperidinyl)-N'-phenylurea
• 英文别名: 1-phenyl-3-(1-propan-2-ylpiperidin-4-yl)urea
• 化学式: C₁₅H₂₃N₃O
• mdl: MFCD06121499
• 分子量: 261.36
• InChiKey: NZRVZIYOUIHPTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  44.4
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• 7-(MORPHOLIN-4-YL)PYRAZOLE[1,5-A]PYRIMIDINE DERIVATIVES WHICH ARE USEFUL FOR THE TREATMENT OF IMMUNE OR INFALMMATORY DISEASES OR CANCER
  申请人：CELON PHARMA S.A.

  公开号：US20180111939A1

  公开（公告）日：2018-04-26

  A compound of the general formula (I) wherein Y represents —CH 2 — or >C=0; R 1 is selected from the group consisting of A1, A2 and A3; R 2 represents dioxothiomorpholino moiety B1, piperazinyl moiety B2, azetidinyl moiety B3, or piperidinyl moiety B4; R 3 is selected from the group consisting of H, halogen, and C1-C4 alkyl; R 4 is selected from the group consisting of C1-C4 alkyl, C3-C4-cycloalkyl, C1-C4 alkyl substituted with C1-C4 alkoxy, and CHF 2 , and their pharmaceutically acceptable salts. Pharmaceutical compositions comprising said compounds and their use in the treatment of diseases of immune system, inflammatory diseases and cancer.