N-Benzyloxycarbonyl-homoanthranilsaeure | 63254-89-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Benzyloxycarbonyl-homoanthranilsaeure
• 英文别名: 2-[[(Phenylmethoxy)carbonyl]amino]benzeneacetic acid；2-[2-(phenylmethoxycarbonylamino)phenyl]acetic acid
• CAS: 63254-89-7
• 化学式: C₁₆H₁₅NO₄
• 分子量: 285.299
• InChiKey: KUPNEAXLOXAEHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Amino-Substituted Ethylamino Beta2 Adrenergic Receptor Agonists
  申请人：Linsell Martin S.

  公开号：US20090111850A1

  公开（公告）日：2009-04-30

  The invention provides novel β 2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β 2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.

  本发明提供了新型的β2肾上腺素能受体激动剂化合物。本发明还提供了包含这些化合物的药物组合物，使用这些化合物治疗与β2肾上腺素能受体活性相关的疾病的方法，以及用于制备这些化合物的过程和中间体。
• EP1981839A1
  申请人：——

  公开号：EP1981839A1

  公开（公告）日：2008-10-22
• Non-Natural Amino Acid Derivatives
  申请人：Hobbs Christopher

  公开号：US20090036525A1

  公开（公告）日：2009-02-05

  Compounds of formula (I) have activity in alleviating the effects of impaired dopaminergic signaling, for example in the treatment of Parkinsons Disease: wherein: R 1 is a carboxyl, carboxyl ester, or carboxamide group; R 2 and R 3 are independently hydrogen, or a group —C(═O)R 6 or —C(═O)OR 6 wherein R 6 is C 1 -C 6 alkyl, or a group —CH 2 Q wherein Q is an optionally substituted monocyclic cycloalkyl or heterocyclyl ring of 3 to 6 ring atoms; R 7 is (i) optionally substituted phenyl or monocyclic heteroaryl, or (ii) a radical of formula —CHR 4 R 5 ; R 4 is (a) optionally substituted C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 2 -C 4 alkenyl, C 2 -C 4 alkenyloxy, or C 2 -C 4 alkynyl, or (b) —CH 2 XCH 3 , —CH 2 CH 2 XCH 3 , or —CH 2 XCH 2 CH 3 , wherein X is —O—, S, or —NR 7 wherein R 7 is hydrogen, methyl or ethyl; or —CH 2 Q or CH 2 OQ wherein Q is as defined in relation to R 6 ; and R 5 is hydrogen, methyl, ethyl, or methyl substituted by 1, 2 or 3 fluoro atoms; or R 4 and R 5 taken together with the carbon atom to which they are attached form an optionally substituted carbocyclic or heterocyclic ring of 3 to 6 ring atoms, optionally fused to a second, optionally substituted, carbocyclic or heterocyclic ring or 3 to 8 ring atoms; PROVIDED THAT the group R 7 is not the side chain of a natural amino acid.
• US4829080A
  申请人：——

  公开号：US4829080A

  公开（公告）日：1989-05-09
• US7964730B2
  申请人：——

  公开号：US7964730B2

  公开（公告）日：2011-06-21