5-(2-Methylpropyl)-1,3-thiazolidine-2,4-dione | 89295-66-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5-(2-Methylpropyl)-1,3-thiazolidine-2,4-dione
• CAS: 89295-66-9
• 化学式: C₇H₁₁NO₂S
• 分子量: 173.24
• InChiKey: XZSGWSPBFIKITE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Methods and compositions of novel triazine compounds
  申请人：Timmer T. Richard

  公开号：US20070099874A1

  公开（公告）日：2007-05-03

  The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

  本发明涉及用于治疗由炎症反应引起的病理生理状态的化合物的方法和组合物。特别地，本发明涉及抑制或阻断糖化蛋白诱导内皮细胞信号相关炎症反应的化合物。本发明涉及抑制平滑肌增殖的化合物。特别地，本发明涉及通过调节HSPG（如Perlecan）来抑制平滑肌细胞增殖的化合物。本发明进一步涉及使用化合物治疗由平滑肌增殖所特征的血管闭塞性疾病，例如再狭窄和动脉粥样硬化。
• Method of promoting nail growth using thyromimetic compounds
  申请人：Doherty Niall S.

  公开号：US20110098303A1

  公开（公告）日：2011-04-28

  The present invention provides methods and compositions for increasing the rate of nail growth in mammals, especially humans, using thyromimetic compounds.
• TETRAHYDRO-BENZOIMIDAZOLYL MODULATORS OF TGR5
  申请人：Janssen Pharmaceutica NV

  公开号：US20170029381A1

  公开（公告）日：2017-02-02

  The present invention comprises compounds of Formula (I). wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , X, Z 1 and Z 2 are defined in the specification.
• US7169785B2
  申请人：——

  公开号：US7169785B2

  公开（公告）日：2007-01-30
• US7238692B2
  申请人：——

  公开号：US7238692B2

  公开（公告）日：2007-07-03