(5Z)-5-[[4-[(E)-(2,5-dioxoimidazolidin-4-ylidene)methyl]phenyl]methylidene]imidazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (5Z)-5-[[4-[(E)-(2,5-dioxoimidazolidin-4-ylidene)methyl]phenyl]methylidene]imidazolidine-2,4-dione
• 化学式: C₁₄H₁₀N₄O₄
• 分子量: 298.25
• InChiKey: GZMJNPDFTRZZQJ-VTBWALSUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Inhibitors of Metastasis, Methods of Generating Such Inhibitors and Their Therapeutic Applications
  申请人：Shah Girish V.

  公开号：US20140286952A1

  公开（公告）日：2014-09-25

  The chain of events that explains calcitonin receptor (CTR)-stimulated invasion and metastasis of prostate cancer cells was identified. The CTR-stimulated events depend on the interaction of CTR with the PDZ3 domain of ZO-1. Small peptides and small molecules were identified that inhibit this interaction. The small inhibitory peptides were synthesized and can be used to attenuate or inhibit metastasis in solid cancer tumors.
• US9765115B2
  申请人：——

  公开号：US9765115B2

  公开（公告）日：2017-09-19
• [EN] INHIBITORS OF METASTASIS, METHODS OF GENERATING SUCH INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS<br/>[FR] INHIBITEURS DE LA MÉTASTASE, PROCÉDÉS DE GÉNÉRATION DE TELS INHIBITEURS ET LEURS APPLICATIONS THÉRAPEUTIQUES
  申请人：UNIV LOUISIANA AT MONROE

  公开号：WO2012135666A1

  公开（公告）日：2012-10-04

  The chain of events that explains calcitonin receptor (CTR)-stimulated invasion and metastasis of prostate cancer cells was identified. The CTR-stimulated events depend on the interaction of CTR with the PDZ3 domain of ZO-1. Small peptides and small molecules were identified that inhibit this interaction. The small inhibitory peptides were synthesized and can be used to attenuate or inhibit metastasis in solid cancer tumors.