(1R,4S,5'S,6R,6'R,8R,10E,12S,13S,14E,16E,20R,21R,24S)-6'-butan-2-yl-21,24-dihydroxy-12-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one;(1R,4S,5'S,6R,6'R,8R,10E,12S,13S,14E,16E,20R,21R,24S)-21,24-dihydroxy-12-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethyl-6'-propan-2-ylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: (1R,4S,5'S,6R,6'R,8R,10E,12S,13S,14E,16E,20R,21R,24S)-6'-butan-2-yl-21,24-dihydroxy-12-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one;(1R,4S,5'S,6R,6'R,8R,10E,12S,13S,14E,16E,20R,21R,24S)-21,24-dihydroxy-12-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethyl-6'-propan-2-ylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
• 化学式: C95H146O28
• 分子量: 1736.2
• InChiKey: SPBDXSGPUHCETR-MVGRHBATSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.81
• 重原子数：
  123
• 可旋转键数：
  15
• 环数：
  14.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  340
• 氢给体数：
  6
• 氢受体数：
  28

文献信息

• Method for the protection of trees
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：US10058098B2

  公开（公告）日：2018-08-28

  The present invention provides a method for the prevention/treatment of bark beetle and/or wood borer infestation of trees comprising treatment of the tree with a composition comprising a macroyclic lactone.

  本发明提供了一种预防/处理树皮甲虫和/或木材蛀虫侵袭树木的方法，包括用一种含有大环内酯的组合物处理树木。
• Electronic ID database and detection method for pesticide compound in edible agro-products based on LC-Q-Orbitrap
  申请人：CHINESE ACADEMY OF INSPECTION AND QUARANTINE

  公开号：US11169128B2

  公开（公告）日：2021-11-09

  Disclosed is an electronic ID database and detection method for pesticide compound in edible agro-products based on LC-Q-Orbitrap. The electronic ID database includes a collection of various pesticides compound electronic ID information, intelligent matching values and collision energies. It is ordered according to the retention time in the electronic ID. The electronic ID contains pesticide compounds information, retention time, adduct ions information, fragment ions information, collision energies, and the optimal full scan mass spectrum. The detection method includes sample pre-treatment, setting LC-Q-Orbitrap operating conditions and sample pesticide residue screening. Setting LC-Q-Orbitrap operating conditions contain setting suitable chromatography and mass spectrometry conditions. In pesticide residue screening procedures, firstly, the retention time is used to find pesticide compounds electronic ID database. If matching, the corresponding electronic ID information is extracted. Then the intelligent matching value is compared, if it is same, the result is recorded and displayed, and the screening is completed.

  本发明公开了一种基于 LC-Q-Orbitrap 的食用农产品中农药化合物电子 ID 数据库及检测方法。电子 ID 数据库包括各种农药化合物电子 ID 信息、智能匹配值和碰撞能量的集合。它根据电子 ID 的保留时间进行排序。电子 ID 包含农药化合物信息、保留时间、加成离子信息、碎片离子信息、碰撞能量和最佳全扫描质谱。检测方法包括样品预处理、设置 LC-Q-Orbitrap 运行条件和样品农药残留筛选。设置 LC-Q-Orbitrap 运行条件包括设置合适的色谱和质谱条件。在农药残留筛选程序中，首先利用保留时间查找农药化合物电子 ID 数据库。如果匹配，则提取相应的电子 ID 信息。然后比较智能匹配值，如果相同，则记录并显示结果，完成筛选。
• Solid injectable veterinary implants comprising monocyclic lactone
  申请人：CEVA SANTE ANIMALE

  公开号：US11318156B2

  公开（公告）日：2022-05-03

  The present invention relates to an injectable implant comprising an effective amount of a macrocyclic lactone, or a salt thereof, and a bioresorbable polymer, and its use in preventing and/or treating parasites infestations in non human mammals, especially pets.

  本发明涉及一种由有效量的大环内酯或其盐和生物可吸收聚合物组成的可注射植入物，及其在预防和/或治疗非人类哺乳动物，尤其是宠物的寄生虫感染中的用途。
• Domesticated household pet food including maintenance amounts of ivermectin
  申请人：RUBICON SCIENTIFIC LLC

  公开号：US20030095996A1

  公开（公告）日：2003-05-22

  Improved ivermectin-containing daily ration extruded feeds for domesticated household pets such as cats and dogs are provided so that a pet consuming the feeds receives quantities of ivermectin sufficient to establish and maintain substantially constant concentrations of the drug in the pet's bloodstream. The feeds are produced by extrusion with addition of minor quantities of ivermectin so as to uniformly distribute the drug throughout the extruded product. Ivermectin levels of from about 2-1500 &mgr;g/kg of extruded feed are preferred.

  本发明提供了用于驯养的家庭宠物（如猫和狗）的改进型含伊维菌素日粮挤压饲料，使食用该饲料的宠物能够摄入足够量的伊维菌素，以建立并维持宠物血液中基本恒定的药物浓度。这种饲料通过挤压生产，并添加少量伊维菌素，以便在整个挤压产品中均匀分布药物。伊维菌素的含量最好为每公斤挤压饲料 2-1500 克。
• Method of preparing domesticated household pet food including maintenance quantities of ivermectin
  申请人：RUBICON SCIENTIFIC LLC.

  公开号：US20030096051A1

  公开（公告）日：2003-05-22

  Improved ivermectin-containing daily ration extruded feeds for domesticated household pets such as cats and dogs are provided so that a pet consuming the feeds receives quantities of ivermectin sufficient to establish and maintain substantially constant concentrations of the drug in the pet's bloodstream. The feeds are produced by extrusion with addition of minor quantities of ivermectin so as to uniformly distribute the drug throughout the extruded product. Ivermectin levels of from about 2-1500 &mgr;g/kg of extruded feed are preferred.

  本发明提供了用于驯养的家庭宠物（如猫和狗）的改进型含伊维菌素日粮挤压饲料，使食用该饲料的宠物能够摄入足够量的伊维菌素，以建立并维持宠物血液中基本恒定的药物浓度。这种饲料通过挤压生产，并添加少量伊维菌素，以便在整个挤压产品中均匀分布药物。伊维菌素的含量最好为每公斤挤压饲料 2-1500 克。