2-[1-(3,3-Diethoxy-prop-1-ynyl)-hexyloxy]-tetrahydro-pyran | 24810-64-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 2-[1-(3,3-Diethoxy-prop-1-ynyl)-hexyloxy]-tetrahydro-pyran
• 英文别名: 2-[(1,1-Diethoxynon-2-YN-4-YL)oxy]oxane；2-(1,1-diethoxynon-2-yn-4-yloxy)oxane
• CAS: 24810-64-8
• 化学式: C₁₈H₃₂O₄
• 分子量: 312.45
• InChiKey: PISDHGZURREKFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[1-(3,3-Diethoxy-prop-1-ynyl)-hexyloxy]-tetrahydro-pyran 在 palladium on activated charcoal 氢气 作用下， 以 乙酸乙酯 为溶剂， 生成 4-Acetoxy-1,1-diethoxynonan
  参考文献：
  名称：

  Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives

  摘要：

  A series of novel (8-aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids has been synthesized and evaluated for their ability to mimic the E series prostaglandins in stimulating cAMP formation in the mouse ovary and in binding to the rat kidney plasma prostaglandin receptor. 7-[2-(3-Hydroxyoctyl)-1,1,4-trioxo-3-thiazolidinyl]heptanoic acid markedly stimulates cAMP formation at reasonable pharmacological concentrations and avidly binds to the rat kidney prostaglandin receptor.

  DOI：

  10.1021/jm00220a013

文献信息

• Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives
  作者：Robert L. Smith、Ta-Jyh Lee、Norman P. Gould、Edward J. Cragoe、Helen G. Oien、Frederick A. Kuehl

  DOI：10.1021/jm00220a013

  日期：1977.10

  A series of novel (8-aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids has been synthesized and evaluated for their ability to mimic the E series prostaglandins in stimulating cAMP formation in the mouse ovary and in binding to the rat kidney plasma prostaglandin receptor. 7-[2-(3-Hydroxyoctyl)-1,1,4-trioxo-3-thiazolidinyl]heptanoic acid markedly stimulates cAMP formation at reasonable pharmacological concentrations and avidly binds to the rat kidney prostaglandin receptor.