1-Phenylethane-1,1-diol | 45777-14-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Phenylethane-1,1-diol
• CAS: 45777-14-8
• 化学式: C₈H₁₀O₂
• 分子量: 138.16
• InChiKey: ACOQMXNUWAWHQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Production Of Enantiopure alpha-Hydroxy Carboxylic Acids From Alkenes By Cascade Biocatalysis
  申请人：NATIONAL UNIVERSITY OF SINGAPORE

  公开号：US20160097063A1

  公开（公告）日：2016-04-07

  The invention provides compositions comprising an alkene epoxidase and a selective epoxide hydrolase, such as a recombinant microorganism comprising a first heterologous nucleic acid encoding an alkene epoxidase and a second heterologous nucleic acid encoding a selective epoxide hydrolase. Exemplary alkene epoxidases include StyAB, while exemplary selective epoxide hydrolases include epoxide hydrolases from Sphingomonas, Solanum tuberosum , or Aspergillus . The invention also provides non-toxic methods of making enantiomerically pure vicinal diols or enantiomerically pure alpha-hydroxy carboxylic acids using these compositions and microorganisms.

  该发明提供了包含烯烃环氧化酶和选择性环氧水解酶的组合物，例如包括编码烯烃环氧化酶的第一异源核酸和编码选择性环氧水解酶的第二异源核酸的重组微生物。示例烯烃环氧化酶包括StyAB，而示例选择性环氧水解酶包括来自Sphingomonas、Solanum tuberosum或Aspergillus的环氧水解酶。该发明还提供了使用这些组合物和微生物制备对映纯邻二醇或对映纯α-羟基羧酸的无毒方法。
• [EN] PREPARATION OF 3,3-DIALKXOY-1-METHYLENEPROPYL ARENES<br/>[FR] PRÉPARATION DE 3,3-DIALKOXY-1-MÉTHYLÈNEPROPYL ARÈNES
  申请人：LONZA AG

  公开号：WO2012150281A1

  公开（公告）日：2012-11-08

  The invention discloses a method for the preparation of 3,3-dialkxoy-1-methylenepropyl arenes from crotonaldehyde and aryldiazonium salts, and intermediates for the preparation of perfumes.

  该发明公开了一种从己烯醛和芳基重氮盐制备3,3-二烷氧基-1-亚甲基丙基芳烃的方法，以及用于制备香水的中间体。
• [EN] FUSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY<br/>[FR] DÉRIVÉS D'IMIDAZOLE TRICYCLIQUES FUSIONNÉS EN TANT QUE MODULATEURS DE L'ACTIVITÉ DU TNF
  申请人：UCB BIOPHARMA SPRL

  公开号：WO2015086527A1

  公开（公告）日：2015-06-18

  A series of substituted fused tricyclic imidazole derivatives, in particular dihydro- 1H-pyrano[4',3':4,5]imidazo[1,2-a]pyridine, 1,2,3,4-tetrahydroimidazo[1,2-a:5,4- c']dipyridine, dihydro-1H-pyrano[3',4':4,5]imidazo[1,2-a]pyridine and tetrahydro-6H- cyclohepta[4,5]imidazo[1,2-a]pyridine, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

  一系列替代的融合三环咪唑衍生物，特别是二氢-1H-吡喃[4',3':4,5]咪唑[1,2-a]吡啶，1,2,3,4-四氢咪唑[1,2-a:5,4-c']二吡啶，二氢-1H-吡喃[3',4':4,5]咪唑[1,2-a]吡啶和四氢-6H-环庚七[4,5]咪唑[1,2-a]吡啶，及其类似物，作为人类TNFα活性的有效调节剂，因此在治疗和/或预防各种人类疾病方面具有益处，包括自身免疫和炎症性疾病；神经学和神经退行性疾病；疼痛和伤害感知性疾病；心血管疾病；代谢性疾病；眼科疾病；以及肿瘤学疾病。
• [EN] SOCE INHIBITORS AND THERAPEUTIC USES THEREOF<br/>[FR] INHIBITEURS DE SOCE ET LEURS UTILISATIONS THÉRAPEUTIQUES
  申请人：INST NAT SANTE RECH MED

  公开号：WO2021233994A1

  公开（公告）日：2021-11-25

  The present invention provides SOCE inhibitors that are useful as therapeutic agents in a variety of applications. The present invention also relates to pharmaceutical compositions, products and kits comprising such SOCE inhibitors, and methods of using the SOCE inhibitors in the treatment of a variety of diseases.

  本发明提供了一种作为治疗剂在各种应用中有用的SOCE抑制剂。本发明还涉及包含这种SOCE抑制剂的药物组合物、产品和试剂盒，以及在治疗各种疾病中使用SOCE抑制剂的方法。
• Methods and Systems for Making Thiol Compounds from Terminal Olefinic Compounds
  申请人：Upshaw Thomas A.

  公开号：US20090264669A1

  公开（公告）日：2009-10-22

  The application discloses thiol ester molecules and α-hydroxy thiol ester molecules having a thiol group located on one of the final two carbon atoms in a carbon chain or a terminal or α-hydroxyl groups, respectively. The disclosed thiol ester molecules and or α-hydroxyl thiol ester molecules es may be made from unsaturated ester molecules having one or more terminal alkene groups. The disclosed techniques also provide methods for making unsaturated ester molecules having one or more terminal alkene groups by the metathesis of unsaturated esters having one or more internal carbon-carbon double bonds (e.g. natural source oils). The thiol ester molecules or α-hydroxy thiol ester molecule may be used in reactions with isocyanate monomers, epoxide monomer, or material having multiple alkene groups to make sealants, coatings, adhesives, and other products.

  本发明揭示了具有巴豆醇基位于碳链的最后两个碳原子之一或具有末端或α-羟基的巴豆醇酯分子和α-羟基巴豆醇酯分子。所述的巴豆醇酯分子或α-羟基巴豆醇酯分子可以由具有一个或多个末端烯烃基团的不饱和酯分子制备而成。本发明还提供了通过不饱和酯类之间的交换反应（例如天然源油）制备具有一个或多个末端烯烃基团的不饱和酯分子的方法。巴豆醇酯分子或α-羟基巴豆醇酯分子可以与异氰酸酯单体，环氧单体或具有多个烯烃基团的材料反应，制备密封剂，涂料，粘合剂和其他产品。