1-(4-Chlorophenyl)-3-[[3-(4-chlorophenyl)imidazolidin-1-yl]methyl]imidazolidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1-(4-Chlorophenyl)-3-[[3-(4-chlorophenyl)imidazolidin-1-yl]methyl]imidazolidine
• 化学式: C₁₉H₂₂Cl₂N₄
• 分子量: 377.316
• InChiKey: OEWCABJGPLJHOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  13
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(2-氨基乙基)-n-(4-氯苯基)胺 在 聚合甲醛 作用下， 以 乙醇 、 水 为溶剂， 生成 1-(4-Chlorophenyl)-3-[[3-(4-chlorophenyl)imidazolidin-1-yl]methyl]imidazolidine
  参考文献：
  名称：

  Synthesis, spectroscopic and biological properties of bis(3-arylimidazolidinyl-1)methanes. A novel family of antimicrobial agents

  摘要：

  Synthesis, spectroscopic and biological properties of new bis('3-arylimidazolidinyl-1)methanes are described. These compounds were synthesized by condensation reaction between N-arylethylenediamines and formaldehyde. Chemical structures were confirmed by means of their H-1- and C-13-NMR and mass spectroscopic data. Investigation of in vitro antimicrobial activity was performed using Gram-negative and Gram-positive bacteria as well as antifungal studies against Aspergillus niger and Candida albicans. Minimal inhibitory concentrations of active compounds were determined. (c) 2005 Published by Elsevier SAS.

  DOI：

  10.1016/j.ejmech.2005.03.010