2-(4-nitrophenyl)-2,4-dihydro-3H-pyrazol-3-one | 1245149-28-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-nitrophenyl)-2,4-dihydro-3H-pyrazol-3-one
• 英文别名: 2-(4-nitrophenyl)-4H-pyrazol-3-one
• CAS: 1245149-28-3
• 化学式: C9H7N3O3
• 分子量: 205.17
• InChiKey: DWZHKXYGTISQMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  78.5
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Methods and kit for hybridization analysis using peptide nucleic acid probes
  申请人：PERSEPTIVE BIOSYSTEMS, INC.

  公开号：EP1477572A2

  公开（公告）日：2004-11-17

  A method, composition and apparatus for the hybridization and separation of molecules having a desired target sequence in a sample by contacting a sample of single stranded nucleic acids with a detectable PNA probe having a sequence complementary to the target sequence so that the target sequence, if present, will hybridize with the detectable probe to form a detectable duplex, and then separating the duplex in a denaturing medium from unbound sample components by electrophoresis. The invention also relates to methods, compositions and apparatus for the hybridization and separation of molecules having a desired target sequence in a mixed sample of single stranded nucleic acids and their complementary strands by contacting the sample with a detectable PNA probe.

  一种用于杂交和分离样品中具有所需目标序列的分子的方法、组合物和装置，其方法是将单链核酸样品与具有与目标序列互补序列的可检测 PNA 探针接触，使目标序列（如果存在）与可检测探针杂交以形成可检测双链，然后在变性介质中通过电泳将双链与未结合的样品成分分离。本发明还涉及通过将样品与可检测的 PNA 探针接触，杂交和分离单链核酸及其互补链混合样品中具有所需目标序列的分子的方法、组合物和装置。
• Methods and kit for hybridization anaylsis using peptide nucleic acid probes
  申请人：Fuchs Martin

  公开号：US20050053944A1

  公开（公告）日：2005-03-10

  A method composition and apparatus for the hybridization and separation of molecules having a desired target sequence in a sample by contacting a sample of single stranded nucleic acids with a detectable PNA probe having a sequence complementary to the target sequence so that the target sequence, if present, will hybridize with the detectable probe to form a detectable duplex, and then separating the duplex in a denaturing medium from unbound sample components by electrophoresis. The invention also relates to methods compositions and apparatus for the hybridization and separation of molecules having a desired target sequence in a mixed sample of single stranded nucleic acids and their complementary strands by contacting the sample with a detectable PNA probe.

  一种用于杂交和分离样品中具有所需目标序列的分子的方法组合物和装置，其方法是将单链核酸样品与具有与目标序列互补的序列的可检测 PNA 探针接触，使目标序列（如果存在）与可检测探针杂交以形成可检测双链，然后在变性介质中通过电泳将双链与未结合的样品成分分离。本发明还涉及在单链核酸及其互补链的混合样品中，通过将样品与可检测的 PNA 探针接触，杂交和分离具有所需目标序列的分子的方法、组合物和装置。
• METHODS AND KIT FOR HYBRIDIZATION ANALYSIS USING PEPTIDE NUCLEIC ACID PROBES
  申请人：PERSEPTIVE BIOSYSTEMS, INC.

  公开号：EP0854937A1

  公开（公告）日：1998-07-29
• APPARATUS AND METHODS FOR SAMPLE ANALYSIS
  申请人：PerSeptive Biosystems, Inc.

  公开号：EP1181541A2

  公开（公告）日：2002-02-27
• APPARATUS AND METHOD FOR SAMPLE ANALYSIS
  申请人：PerSeptive Biosystems, Inc.

  公开号：EP1181541B1

  公开（公告）日：2005-03-16