[[(E)-(5-oxopyridin-2-ylidene)methyl]amino]thiourea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: [[(E)-(5-oxopyridin-2-ylidene)methyl]amino]thiourea
• 化学式: C₇H₈N₄OS
• 分子量: 196.23
• InChiKey: GEGFVWJYBMMYFN-HWKANZROSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• IRON CHELATORS IN TUMOR THERAPY
  申请人：Deutsches Krebsforschungszentrum

  公开号：EP3713573A1

  公开（公告）日：2020-09-30
• [EN] IRON CHELATORS IN TUMOR THERAPY<br/>[FR] CHÉLATEURS DU FER EN THÉRAPIE ANTITUMORALE
  申请人：DEUTSCHES KREBSFORSCH

  公开号：WO2019101897A1

  公开（公告）日：2019-05-31

  The present invention relates to a pharmaceutically compatible iron chelator or a prodrug thereof for use in treating and/or preventing cancer in a subject suspected or known to comprise hypoxic cancer cells, and use in treatment and/or prevention of a human papillomavirus (HPV) related lesion. The present invention further relates to a use of an iron chelator or prodrug thereof for inducing senescence in a cancer cell, preferably a hypoxic cancer cell; and to a method for inducing an irreversible proliferation arrest in cancer cells comprising a) contacting said cancer cells with an iron chelator or prodrug thereof and, thereby, b) inducing an irreversible proliferation arrest in said cancer cells.
• [EN] TREATMENT OF STAT3 RELATED DISEASES BY IRON CHELATORS<br/>[FR] TRAITEMENT DE MALADIES LIÉES À LA STAT3 PAR DES CHÉLATEURS DE FER
  申请人：DEUTSCHES KREBSFORSCH

  公开号：WO2021078937A1

  公开（公告）日：2021-04-29

  The present invention relates to a pharmaceutically compatible iron chelator or prodrug thereof for use in treating and/or preventing a disease caused or aggravated by STAT3 hyperactivity in effector cells in a subject; and to methods, kits, devices, uses, and combined preparations