[2-氧代-2-[2-(2-氧代咪唑烷-1-基)乙基氨基]乙基]2-甲基丙-2-烯酸酯 | 3089-23-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: [2-氧代-2-[2-(2-氧代咪唑烷-1-基)乙基氨基]乙基]2-甲基丙-2-烯酸酯
• 中文别名: 乙酮,2-溴-1-(5-氟-2-甲氧苯基)-
• 英文名称: N-(2-Methacryloyloxyacetamino-aethyl)-N,N'-aethylen-harnstoff
• 英文别名: 2-methyl-acrylic acid [2-(2-oxo-imidazolidin-1-yl)-ethylcarbamoyl]-methyl ester；methacryloyloxy-acetic acid-[2-(2-oxo-imidazolidin-1-yl)-ethylamide]；Methacryloyloxy-essigsaeure-[2-(2-oxo-imidazolidin-1-yl)-aethylamid]；2-oxo-2-{[2-(2-oxoimidazolidin-1-yl)ethyl]amino}ethyl methacrylate；N-(beta-(2-Methacryloxyacetamido)ethyl)ethylene urea；[2-oxo-2-[2-(2-oxoimidazolidin-1-yl)ethylamino]ethyl] 2-methylprop-2-enoate
• CAS: 3089-23-4
• 化学式: C₁₁H₁₇N₃O₄
• 分子量: 255.274
• InChiKey: BMMZGRLRFPSWKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  87.7
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2933990090

文献信息

• [EN] ALPHA-CARBOLINES FOR THE TREATMENT OF CANCER<br/>[FR] ALPHA-CARBOLINES POUR LE TRAITEMENT DU CANCER
  申请人：UNIV MILANO BICOCCA

  公开号：WO2013167730A1

  公开（公告）日：2013-11-14

  The present invention relates to inhibitors of the oncogenic protein kinase ALK of formula (I) as herein described and pharmaceutical compositions thereof, as well as to key intermediates towards their synthesis. The compounds of formula (I) are useful in the preparation of a medicament, in particular for the treatment of cancer.

  本发明涉及如下式（I）所述的致癌蛋白激酶ALK的抑制剂及其药物组合物，以及用于其合成的关键中间体。式（I）的化合物在制备药物中具有用途，特别是用于癌症治疗。
• Preparation Comprising at Least One Conazole Fungicide
  申请人：Koltzenburg Sebastian

  公开号：US20080318785A1

  公开（公告）日：2008-12-25

  The invention relates to preparations, in particular plant-protective preparations which contain a mixture of at least two different active plant-protective substances, wherein a) at least one active substance is selected from a conazole group (active substance 1) and b) another active plant-protective substance (active substance 2) whose water solubility at a temperature of 20° C. is less than 20 g/l, c) at least one type of copolymer CP consisting of M monomers comprising α) at least one type of monoethylenically unsaturated monomer M1 comprising at least one sulphonic acid group and β) at least one type of neutral monoethylenically unsaturated monomer M2, wherein the quantitative ratio between the active substance 1 and the other active plant-protective substance 2 ranges from 1:10 to 10:1. Said invention also relates to novel copolymers CP which are embodied in the form of polymers consisting of at least three types of different monoethylenically unsaturated monomers M and comprise, in the polymerisation incorporated form, α) at least one type of monoethylenically unsaturated monomer M1 comprising at least one sulphonic acid group, β1) at least one type of neutral monoethylenically unsaturated monomer M2 whose water solubility at a temperature of 20° C. is less than 30 g/l and β2) at least one type of neutral monoethylenically unsaturated monomer M2b whose water solubility at a temperature of 20° C. is greater than 50 g/l.

  该发明涉及制剂，特别是包含至少两种不同活性植物保护物质混合物的植物保护制剂，其中a) 至少一种活性物质选自庚唑类（活性物质1），b) 另一种活性植物保护物质（活性物质2）其在20°C温度下的水溶性小于20 g/l，c) 至少一种由M单体组成的共聚物CP，包括α) 至少一种含有至少一个磺酸基团的单乙烯不饱和单体M1，β) 至少一种中性单乙烯不饱和单体M2，其中活性物质1和另一种活性植物保护物质2之间的定量比例范围为1:10至10:1。该发明还涉及新型共聚物CP，其以至少三种不同单乙烯不饱和单体M组成，并在聚合体中包含α) 至少一种含有至少一个磺酸基团的单乙烯不饱和单体M1，β1) 至少一种中性单乙烯不饱和单体M2，其在20°C温度下的水溶性小于30 g/l，β2) 至少一种中性单乙烯不饱和单体M2b，其在20°C温度下的水溶性大于50 g/l。
• PRECIPITATION POLYMERIZATION IN THE PRESENCE OF GLYCERIN MONOSTEARATE
  申请人：KIM Son Nguyen

  公开号：US20110150796A1

  公开（公告）日：2011-06-23

  A process for preparing a copolymer composition A) by free-radical copolymerization of a monomer composition comprising: a) acrylic acid, b) optionally at least one compound, different from a), having a free-radically polymerizable, α,β-ethylenically unsaturated double bond and at least one anionogenic and/or anionic group per molecule, c) at least one free-radically polymerizable crosslinking compound which comprises at least two α,β-ethylenically unsaturated double bonds per molecule. The process is performed by precipitation polymerization in the presence of an auxiliary composition H) comprising H1) glycerol monostearate, and H2) at least one compound with an HLB value in the range from 4 to 10, selected from water-insoluble natural waxes, nonionic emulsifiers and mixtures thereof.

  一种制备共聚物组合物A的方法，包括以下步骤：A)通过自由基共聚合反应制备单体组合物，所述单体组合物包括：a)丙烯酸，b)选择性地至少包括一种与a)不同的化合物，其具有自由基聚合能力的α，β-乙烯基不饱和双键和至少一个分子中的阴离子和/或阴离子基团，c)至少包括一种自由基聚合交联剂，其包括每个分子中至少两个α，β-乙烯基不饱和双键。该方法通过在辅助组成物H的存在下进行沉淀聚合反应，所述辅助组成物H包括H1)单硬脂酸甘油酯，和H2)HLB值在4到10范围内的至少一种化合物，所述化合物选自不溶于水的天然蜡、非离子乳化剂和它们的混合物。
• TITANIUM DIOXIDE COMPOSITION COMPRISING TITANIUM DIOXIDE NANOPARTICLES, AND PREPARATION AND USE THEREOF
  申请人：Bette Virginie

  公开号：US20110143923A1

  公开（公告）日：2011-06-16

  The present invention relates to a titanium dioxide composition which comprises titanium dioxide nanoparticles, its preparation and use.

  本发明涉及一种钛白粉组成物，包括钛白粉纳米颗粒，其制备和使用。
• Latex composition for water based paints and process for making same
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP0009880A1

  公开（公告）日：1980-04-16

  A latex composition particularly suited as a paint vehicle for the manufacture of semi-gloss and flat interior paint compositions comprises from 40 to 70% by weight of polymerized resin particles having at least 25% (by weight) vinyl acetate polymerized therein, the particles being substantially spherical and characterized in that not more than 5%of the particles have a diameter greater than 0.65 microns and not more than 5% have a diameter less than 0.33 microns. In the preferred instance, the polymer resin particles comprise vinyl acetate, a lower alkyl acrylate and a conventional wet adhesion monomer, the combination consisting (by weight) of from 80 to 90% vinyl acetate, 10 to 20% of lower alkyl acrylate, e.g., butyl acrylate and 0.2 to 1.5% of wet adhesion monomer.

  一种乳胶组合物特别适合用作制造半光和平光内墙涂料组合物的涂料载体，它包括 40% 至 70% （按重量计）的聚合树脂颗粒，其中聚合了至少 25% （按重量计）的醋酸乙烯酯，这些颗粒基本上是球形的，其特征在于不超过 5% 的颗粒直径大于 0.65 微米，不超过 5% 的颗粒直径小于 0.33 微米。在优选情况下，聚合物树脂颗粒由乙酸乙烯酯、低级烷基丙烯酸酯和常规湿粘合单体组成，其组合（按重量计）包括 80% 至 90% 的乙酸乙烯酯、10% 至 20% 的低级烷基丙烯酸酯（如丙烯酸丁酯）和 0.2% 至 1.5% 的湿粘合单体。