(4-Fluorobenzyl)-(3-(pyridin-4-yl)-1-(2-(pyridin-4-yl)ethyl)propyl)amine | 179033-45-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-Fluorobenzyl)-(3-(pyridin-4-yl)-1-(2-(pyridin-4-yl)ethyl)propyl)amine
• 英文别名: N-[(4-fluorophenyl)methyl]-1,5-dipyridin-4-ylpentan-3-amine
• CAS: 179033-45-5
• 化学式: C₂₂H₂₄FN₃
• 分子量: 349.451
• InChiKey: AGEPMEZDBYBLIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] METHODS AND COMPOSITIONS FOR STIMULATING NEURITE GROWTH USING COMPOUNDS WITH AFFINITY FOR FKBP12 IN COMBINATION WITH NEUROTROPHIC FACTORS<br/>[FR] METHODES ET COMPOSITIONS UTILISES POUR LA STIMULATION DE LA CROISSANCE DES NEURITES, DANS LESQUELLES ON UTILISE DES COMPOSES PRESENTANT UNE AFFINITE POUR LE FKBP12 ASSOCIES A DES FACTEURS NEUROTROPHIQUES
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：WO1998020891A1

  公开（公告）日：1998-05-22

  (EN) The present invention relates to methods and pharmaceutical compositions for stimulating the growth of neurites in nerve cells. The compositions comprise a neurotrophic amount of a compound and a neurotrophic factor, such as nerve growth factor (NGF). The methods comprise treating nerve cells with the above compositions or compositions comprising the compound without a neurotropic factor. The methods of this invention can be used to promote repair of neuronal damage caused by disease or physical trauma.(FR) L'invention porte sur des méthodes et des compositions pharmaceutiques utilisées pour la stimulation de la croissance des neurites des cellules nerveuses. Lesdites compositions comprennent une quantité à effet neurotrophique d'un composé et d'un facteur neurotrophique tel que le facteur de croissance des nerfs (NGF). Lesdites méthodes consistent à traiter les cellules nerveuses à l'aide des susdites compositions ou de compositions comprenant le composé mais pas de facteur de croissance neurotrophique. Les méthodes de l'invention peuvent servir à promouvoir la réparation de lésions neurales dues à une maladie ou à un traumatisme physique.

  本发明涉及用于刺激神经细胞中神经元突起生长的方法和制药组合物。该组合物包括一种化合物和一种神经营养因子，例如神经生长因子（NGF），其中含有神经营养剂量。该方法包括使用上述组合物或仅包含该化合物而不含神经营养因子的组合物来治疗神经细胞。本发明的方法可用于促进由疾病或物理创伤引起的神经损伤的修复。
• Novel amino acid derivatives with improved multi-drug resistance activity
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1420009A2

  公开（公告）日：2004-05-19

  The present invention relates to compounds that can meintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multi-drug resistant cancer therapy.

  本发明涉及可保持、增加或恢复细胞对治疗或预防药物敏感性的化合物。本发明还涉及包含这些化合物的药物组合物。本发明的化合物和药物组合物尤其适用于治疗耐多药细胞、预防耐多药细胞的发展以及用于耐多药癌症治疗。
• NOVEL AMINO ACID DERIVATIVES WITH IMPROVED MULTI-DRUG RESISTANCE ACTIVITY
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：EP0797567B1

  公开（公告）日：2004-02-11
• METHODS AND COMPOSITIONS FOR STIMULATING NEURITE GROWTH USING COMPOUNDS WITH AFFINITY FOR FKBP12 IN COMBINATION WITH NEUROTROPHIC FACTORS
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP0946190A1

  公开（公告）日：1999-10-06
• METHODS AND COMPOSITIONS FOR STIMULATING NEURITE OUTGROWTH
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP0946190B1

  公开（公告）日：2003-09-24