[2-氯乙氧基(苯基)磷酰基]苯 | 92982-05-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: [2-氯乙氧基(苯基)磷酰基]苯
• 英文名称: 2-chloroethyl diphenylphosphinate
• 英文别名: [2-chloroethoxy(phenyl)phosphoryl]benzene
• CAS: 92982-05-3
• 化学式: C₁₄H₁₄ClO₂P
• 分子量: 280.691
• InChiKey: KYVSULMJNCIHRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  碳酸乙烯酯 、 二苯基次膦酰氯 在 碳酸胍 作用下， 以65.3%的产率得到[2-氯乙氧基(苯基)磷酰基]苯
  参考文献：
  名称：

  Synthesis of Phosphorus Derivatives from 1,3-Dioxolan-2-one

  摘要：

  A new route for the synthesis of some mixed organic phosphorus compounds from 1,3-dioxolan-2-one is reported. By heating a mixture of phosphorus-chlorine derivatives and 1,3-dioxolan-2-one in the presence of a catalyst, mixed phosphorus derivatives having 2-chloroethyl ester groups could be obtained. A wide range of phosphorus derivatives can be obtained using this method.

  DOI：

  10.1080/714040962

文献信息

• A solvent-free method for the preparation of phosphinates from P(O)-OH compounds with alkyl chlorides
  作者：Huihui Yuan、Mingyue Wang、Lei Fan、Jia Yang、Shuai Wang、Hong Zhong

  DOI：10.1016/j.tetlet.2021.153529

  日期：2021.12

  Herein, a new solvent-free synthetic method using P(O)-OH compound and alkyl chloride for phosphinate compounds is disclosed. This transformation proceeds smoothly under the promotion of a lone base and presents the advantages of an easily available raw material source, a simple post treatment process, good functional group tolerance and high reaction efficiency. Good yield was obtained when the reaction

  在此，公开了一种使用P(O)-OH化合物和烷基氯制备次膦酸盐化合物的无溶剂合成新方法。这种转化在孤碱的推动下顺利进行，具有原料来源易得、后处理工艺简单、官能团耐受性好、反应效率高等优点。当反应放大至克级时，收率良好，P(O)-OH化合物与烷基氯化物的摩尔比可降至1:2。该协议为制备磷衍生物提供了一种实用的方法。此外，通过31 P NMR探索了反应机理。
• Synthesis of Phosphorus Derivatives from 1,3-Dioxolan-2-one
  作者：Gheorghe Ilia、Alina Bora、Smaranda Iliescu、Adriana Popa、Gheorghe Dehelean

  DOI：10.1080/714040962

  日期：2003.11.1

  A new route for the synthesis of some mixed organic phosphorus compounds from 1,3-dioxolan-2-one is reported. By heating a mixture of phosphorus-chlorine derivatives and 1,3-dioxolan-2-one in the presence of a catalyst, mixed phosphorus derivatives having 2-chloroethyl ester groups could be obtained. A wide range of phosphorus derivatives can be obtained using this method.