N-Phenyl methyl-2 hexane lactame-6 | 75737-58-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: N-Phenyl methyl-2 hexane lactame-6
• 英文别名: 3-Methyl-1-phenylazepan-2-one
• CAS: 75737-58-5
• 化学式: C₁₃H₁₇NO
• 分子量: 203.284
• InChiKey: NWHIEPCGGDTSOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (Methyl-2 cyclohexane)-1-spiro-3'-(phenyl-2' oxaziridine) 反应 672.0h， 生成 N-Phenyl methyl-6 hexane lactame-6 、 N-Phenyl methyl-2 hexane lactame-6
  参考文献：
  名称：

  Structural determination of ε-lactams by ¹ H and ¹³ C NMR

  摘要：

  AbstractThe thermodynamic products (ε‐lactams) of the degradation of ten different spirocyclic oxaziridines were analyzed by 1H and 13C NMR spectroscopy. The preferred conformations were determined by examining the homonuclear spin–spin coupling constant and the chemical shift effects of the N‐substituent and the alkyl group of the aliphatic ring on 1H and 13C NMR spectra. Copyright © 2009 John Wiley & Sons, Ltd.

  DOI：

  10.1002/mrc.2504

文献信息

• STAT6 inhibitors
  申请人：Board of Regents, The University of Texas System

  公开号：US10385080B2

  公开（公告）日：2019-08-20

  The present disclosure provides compounds that are useful for inhibiting the STAT6 pathway. Also provided are related pharmaceutical compositions and methods of using the compounds. In some embodiments, the compounds may be used to treat a disease such as, e.g., an allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease, or a cancer.

  本公开提供了可用于抑制 STAT6 通路的化合物。还提供了相关的药物组合物和使用这些化合物的方法。在一些实施方案中，化合物可用于治疗疾病，如过敏性肺病、过敏性鼻炎、慢性肺阻塞性疾病或癌症。
• Oliveros, Esther; Riviere, Monique; Lattes, Armand, Journal of Heterocyclic Chemistry, 1980, vol. 17, p. 1025 - 1027
  作者：Oliveros, Esther、Riviere, Monique、Lattes, Armand

  DOI：——

  日期：——
• STAT6 INHIBITORS
  申请人：Board of Regents, The University of Texas System

  公开号：US20160145279A1

  公开（公告）日：2016-05-26

  The present disclosure provides compounds that are useful for inhibiting the STAT6 pathway. Also provided are related pharmaceutical compositions and methods of using the compounds. In some embodiments, the compounds may be used to treat a disease such as, e.g., an allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease, or a cancer.
• US9765099B2
  申请人：——

  公开号：US9765099B2

  公开（公告）日：2017-09-19
• Structural determination of ε-lactams by ¹ H and ¹³ C NMR
  作者：Rubén Montalvo-González、Armando Ariza-Castolo

  DOI：10.1002/mrc.2504

  日期：2009.12

  AbstractThe thermodynamic products (ε‐lactams) of the degradation of ten different spirocyclic oxaziridines were analyzed by 1H and 13C NMR spectroscopy. The preferred conformations were determined by examining the homonuclear spin–spin coupling constant and the chemical shift effects of the N‐substituent and the alkyl group of the aliphatic ring on 1H and 13C NMR spectra. Copyright © 2009 John Wiley & Sons, Ltd.