N-(5-Phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)-acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-(5-Phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)-acetamide
• 英文别名: Pyrazolopyridine deriv. 9；N-(5-phenyl-2H-pyrazolo[3,4-b]pyridin-3-yl)acetamide
• 化学式: C₁₄H₁₂N₄O
• 分子量: 252.275
• InChiKey: OGLXQFQATMRTEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  70.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] PYRAZOLOPYRIDINE DERIVATIVES<br/>[FR] DERIVES DE PYRAZOLOPYRIDINE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2003045949A1

  公开（公告）日：2003-06-05

  Compounds of formula (I), or a salt thereof, or a solvate thereof, wherein, R 1 is halo, -N=N-heteroaryl, -CO2R5, -NHCH2R6; or -CONR7R8; R2 is H or aryl; R3 is H or aryl, wherein the aryl ring may be optionally substituted by one or more substituents, which may be the same or different, selected from halo; R4 is H; R5 is alkyl; and R6 is H, alkyl, cycloalkyl, aryl or aralkyl; R7 and R8 are selected from H and alkyl; and with the proviso that when R1 is halo, at least one of R2 and/or R3 is aryl; a process for preparing such compounds, a pharmaceutical composition comprising such compounds and the use of such compounds and composition in medicine.