Pyrazolopyridine deriv. 18 | 405221-39-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Pyrazolopyridine deriv. 18
• 英文别名: N-[5-(2-fluorophenyl)-2H-pyrazolo[3,4-b]pyridin-3-yl]butanamide
• CAS: 405221-39-8
• 化学式: C₁₆H₁₅FN₄O
• 分子量: 298.32
• InChiKey: UJSQNTWNRHAOBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  70.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Compositions And Methods For Inhibiting Expression Of GSK-3 Genes
  申请人：Sah Dinah Wen-Yee

  公开号：US20110184046A1

  公开（公告）日：2011-07-28

  The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting Glycogen Synthase Kinase-3 (GSK-3), and methods of using the dsRNA to inhibit expression of GSK-3.

  这项发明涉及一种靶向糖原合成酶激酶-3（GSK-3）的双链核糖核酸（dsRNA），以及使用该dsRNA抑制GSK-3表达的方法。
• Use of a GSK-3 Inhibitor to Maintain Potency of Cultured Cells
  申请人：Mays Robert W.

  公开号：US20120009674A1

  公开（公告）日：2012-01-12

  The present invention is directed to the culture of non-embryonic cells, that can differentiate into cell types of more than one embryonic lineage, in culture under conditions that maintain differentiation capacity during expansion; more particularly, culturing non-embryonic cells in the presence of at least one GKS-3 inhibitor, such as BIO.
• VALPROIC ACID COMPOUNDS AND WNT AGONISTS FOR TREATING EAR DISORDERS
  申请人：Frequency Therapeutics, Inc.

  公开号：US20220133740A1

  公开（公告）日：2022-05-05

  The present invention provides methods for treating diseases and disorders of the ear with valproic acid compounds and Wnt agonists. The present invention further provides kits for the same.
• HYDROGEL DRUG DELIVERY COMPOSITION
  申请人：Board of Regents of the University of Nebraska

  公开号：US20220218571A1

  公开（公告）日：2022-07-14

  Disclosed is a hydrogel drug delivery composition comprising a therapeutic agent and a poloxamer, wherein the poloxamer is modified to be capable of adhering to a surface of bones or teeth, and wherein the poloxamer is modified by pyrophosphate, bisphosphonates, acidic peptides or tetracycline and its derivatives.
• US9029525B2
  申请人：——

  公开号：US9029525B2

  公开（公告）日：2015-05-12