3,4,4'-Triamino-diphenyl | 17828-45-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4,4'-Triamino-diphenyl
• 英文别名: [1,1'-Biphenyl]-3,4,4'-triamine；4-(4-aminophenyl)benzene-1,2-diamine
• CAS: 17828-45-4
• 化学式: C₁₂H₁₃N₃
• 分子量: 199.255
• InChiKey: RVYIVHUVZXDTGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.1
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] PROCESS FOR THE PREPARATION OF RIDINILAZOLE AND CRYSTALLINE FORMS THEREOF<br/>[FR] PROCÉDÉ DE PRÉPARATION DE RIDINILAZOLE ET DE FORMES CRISTALLINES DE CELUI-CI
  申请人：SUMMIT OXFORD LTD

  公开号：WO2021009514A1

  公开（公告）日：2021-01-21

  Described are processes for the preparation of 2,2'-di(pyridin-4-yl)-1H,1'H-5,5'- bibenzo[d]imidazole (which may also be known as 5,5'bis-[2-(4-pyridinyl)-1H- benzimidazole]), referenced herein by the INN name ridinilazole, and pharmaceutically acceptable derivatives, salts, hydrates, solvates, complexes, bioisosteres, metabolites or prodrugs thereof. The invention also relates to various compositions of purified ridinilazole, to various crystalline forms of ridinilazole, to processes for their preparation and to related pharmaceutical preparations and uses thereof (including their medical use and their use in the efficient large-scale synthesis of ridinilazole).

  介绍了制备2,2'-二(吡啶-4-基)-1H,1'H-5,5'-双苯并[d]咪唑(也可以被称为5,5'-双-[2-(4-吡啶基)-1H-苯并咪唑])的过程，该化合物在此处以国际非专利药品名称ridinilazole命名，以及其药学上可接受的衍生物、盐、水合物、溶剂化物、配合物、生物等效物、代谢物或前药。本发明还涉及纯化ridinilazole的各种组合物、ridinilazole的各种晶体形式、其制备过程以及相关的制药制剂和用途(包括其医学用途和在ridinilazole的高效大规模合成中的应用)。
• COMPOUNDS FOR THE TREATMENT OF CANCERS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS
  申请人：Piramal Swati Ajay

  公开号：US20140142159A1

  公开（公告）日：2014-05-22

  The present invention relates to the pyrrolidine substituted with flavone derivatives, represented by the compounds of Formula (I) or a pharmaceutically acceptable salt, a solvate, a stereoisomer or a diastereoisomer thereof for use in the treatment of cancers associated with human papillomavirus. The present invention also relates to the pharmaceutical compositions containing the compounds of Formula (I) for the treatment of cancers associated with human papillomavirus.

  本发明涉及用于治疗与人类乳头瘤病毒相关的癌症的嘧啶替代黄酮衍生物，其由式（I）的化合物或其药学上可接受的盐、溶剂化物、立体异构体或对映异构体表示。本发明还涉及含有式（I）化合物的药物组合物，用于治疗与人类乳头瘤病毒相关的癌症。
• Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides
  申请人：Ryan, James Walter

  公开号：EP0073143A2

  公开（公告）日：1983-03-02

  Novel inhibitors of angiotensin converting enzyme are disclosed which have the general formula wherein R, and/or R3 form complex amides and imides thereof, X = S, O or NR3, R4 and Rs form with -N-C- a 4-6 membered ring structure as described and the other R substituents are selected from a variety of disclosed groups.

  已公开的新型血管紧张素转换酶抑制剂具有通式 其中 R 和/或 R3 形成其复合酰胺和亚胺，X = S、O 或 NR3，R4 和 Rs 与 -N-C- 形成所述的 4-6 分子环结构，其他 R 取代基选自各种已公开的基团。
• Two stage melt polymerization process for making polybenzimidazoles
  申请人：HOECHST CELANESE CORPORATION

  公开号：EP0705863A1

  公开（公告）日：1996-04-10

  The present invention is directed to a two stage melt polymerization process for producing polybenzimidazoles and aromatic amide polymers. The process includes the steps of: 1) providing a mixture of an aromatic amine, a dicarboxylic component, and a foaming agent; 2) heating the mixture to a condensation polymerization temperature in a first stage under a substantially oxygen-free atmosphere; 3) maintaining the mixture at that temperature, but in no event at a temperature greater than 350°C while allowing a friable foam to form; 4) cooling the foam; 5) crushing the foam to obtain a prepolymer; and 6) heating the prepolymer in a second stage, to a temperature in excess of the highest temperature employed in the first stage, under a substantially oxygen-free atmosphere, and until a desired inherent viscosity is obtained.

  本发明涉及一种生产聚苯并咪唑和芳香族酰胺聚合物的两阶段熔融聚合工艺。该工艺包括以下步骤1）提供由芳香胺、二羧酸组分和发泡剂组成的混合物；2）在第一阶段，在基本无氧的气氛下，将混合物加热到缩合聚合温度；3）将混合物保持在该温度，但在任何情况下都不能超过 350℃，同时允许形成易碎泡沫；4) 冷却泡沫； 5) 粉碎泡沫，得到预聚物； 6) 在第二阶段，在基本无氧的环境下，将预聚物加热到超过第一阶段最高温度的温 度，直到获得所需的固有粘度。
• Antibodies, production method of the antibodies, hybridomas which produce the antibodies, production method of the hybridomas and antigen proteins recognized by the antibodies
  申请人：Kawai, Makoto

  公开号：EP0943625A1

  公开（公告）日：1999-09-22

  The invention is related to antibodies which specifically react with connective tissue type-human mast cells, a production method of the antibodies, hybridomas which produce the antibodies, a production method of the hybridomas and antigen proteins recognized by the antibodies. After cord blood cells were cultured in the presence of SCF and IL-6, they were further cocultured with primary culture of human skin fibroblasts, and connective tissue type-human mast cells were thus obtained. A rat was immunized using the cells, hybridomas were prepared and selected by an ordinary method, and novel monoclonal antibodies were harvested from the culture supernatant of the selected hybridomas. The monoclonal antibodies specifically reacted with connective tissue type-human mast cells.

  本发明涉及与结缔组织型人类肥大细胞特异性反应的抗体、抗体的生产方法、产生抗体的杂交瘤、杂交瘤的生产方法和抗体识别的抗原蛋白。在 SCF 和 IL-6 存在下培养脐带血细胞后，进一步与原代培养的人类皮肤成纤维细胞共培养，从而获得结缔组织型人类肥大细胞。使用这些细胞对大鼠进行免疫，用普通方法制备和筛选杂交瘤，并从筛选出的杂交瘤培养上清液中获得新型单克隆抗体。这种单克隆抗体能与结缔组织型人类肥大细胞发生特异性反应。