1-[N'-[6-[[amino-[(N'-hexylcarbamimidoyl)amino]methylidene]amino]hexyl]carbamimidoyl]-2-hexylguanidine | 109752-54-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-[N'-[6-[[amino-[(N'-hexylcarbamimidoyl)amino]methylidene]amino]hexyl]carbamimidoyl]-2-hexylguanidine
• CAS: 109752-54-7
• 化学式: C₂₂H₄₈N₁₀
• 分子量: 452.69
• InChiKey: QOLLFTYOMPFPDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  32
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  178
• 氢给体数：
  6
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-氨基-1-己烷氯化铵 以 正丁醇 为溶剂， 反应 10.0h， 生成 1-[N'-[6-[[amino-[(N'-hexylcarbamimidoyl)amino]methylidene]amino]hexyl]carbamimidoyl]-2-hexylguanidine
  参考文献：
  名称：

  口腔消毒剂抑制抗凋亡蛋白Bcl-xL介导的蛋白质-蛋白质相互作用，并诱导人口腔肿瘤细胞凋亡。

  摘要：

  长期以来，洗必泰和阿莱西丁已被人类用作口服消毒剂。两种化合物均在生理相关浓度下抑制抗凋亡蛋白Bcl-x L介导的蛋白-蛋白相互作用，并诱导一系列源自舌头和咽部的肿瘤细胞系的凋亡（见图）。抑制蛋白质之间的相互作用是当前人类使用药物的一种潜在作用方式。

  DOI：

  10.1002/anie.201208889

文献信息

• In vitro antiplaque properties of a series of alkyl bis(biguanides)
  作者：Robert A. Coburn、Pamela J. Baker、Richard T. Evans、Robert J. Genco、Stuart L. Fischman

  DOI：10.1021/jm00206a024

  日期：1978.8

  A series of eight alkyl bis(biguanide) analogues of alexidine, N,N''''-1,6-hexanediyl bis[N'-(2-ethylhexyl)imidodicarbonimidic diamide] (1), was prepared. Five of these analogues constituted a series isolipophilic with 1 but with varying bridge length between biguanide moieties. The compounds were evaluated in vitro for antibacterial and antiplaque properties against Streptococcus mutans, Actinomyces

  制备了一系列的八个亚立定啶的烷基双（双胍）类似物，N，N″′-1，6-己二基双[N′-（2-乙基己基）亚氨基二碳二酰亚胺二酰胺]（1）。这些类似物中的五个构成了一系列亲脂性的，具有1个，但双胍部分之间的桥长不同。在体外评估了化合物对变形链球菌，粘性放线菌和内生放线菌的抗菌和抗菌斑特性。一种类似物NN，''''-1,6-己二基双[N'（n-（正辛基）亚氨基二碳二酰亚胺二酰胺]]似乎比1或洗必泰对这种形成牙菌斑的微生物更有效。
• CURABLE-ON-DEMAND COMPOSITION COMPRISING DUAL REACTIVE SILANE FUNCTIONALITY
  申请人：Yang Yu

  公开号：US20130178553A1

  公开（公告）日：2013-07-11

  A curable composition comprises (a) at least one inorganic or organic compound comprising reactive silane functionality comprising at least one hydrosilyl moiety; (b) at least one inorganic or organic compound comprising reactive silane functionality comprising at least one hydroxysilyl moiety, the hydroxysilyl moiety optionally being generated in situ by hydrolysis of at least one hydrosilyl moiety; and (c) at least one photoactivatable composition that, upon exposure to radiation, generates at least one base selected from amidines, guanidines, phosphazenes, proazaphosphatranes, and combinations thereof; with the proviso that, when component (a) is an organic polymer, then component (b) is different from component (a) and is not generated in situ by hydrolysis of component (a).

  一种可治愈的组合物包括：（a）至少一种含有反应性硅烷官能团的无机或有机化合物，其中硅烷官能团包括至少一个氢硅烷基；（b）至少一种含有反应性硅烷官能团的无机或有机化合物，其中硅烷官能团包括至少一个羟基硅烷基，羟基硅烷基可以通过至少一个氢硅烷基的水解而在原位生成；以及（c）至少一种光活性组合物，当暴露于辐射下时，生成至少一种从氨基甲酸酰胺、鸟嘌呤、磷氮烷、丙氨酸磷酸酯和其组合物中选择的碱，前提是当组分（a）是有机聚合物时，组分（b）与组分（a）不同，并且不是通过组分（a）的水解在原位生成的。
• CURABLE-ON-DEMAND POLYSILOXANE COATING COMPOSITION
  申请人：Yang Yu

  公开号：US20130101841A1

  公开（公告）日：2013-04-25

  A curable composition comprises (a) at least one polydiorganosiloxane, fluorinated polydiorganosiloxane, or combination thereof comprising reactive silane functionality comprising at least two hydroxysilyl moieties; (b) at least one polydiorganosiloxane, fluorinated polydiorganosiloxane, or combination thereof comprising reactive silane functionality comprising at least two hydrosilyl moieties; and (c) at least one photoactivatable composition that, upon exposure to radiation, generates at least one base selected from amidines, guanidines, phosphazenes, proazaphosphatranes, and combinations thereof; wherein at least one of the components (a) and (b) has an average reactive silane functionality of at least three.

  可治疗组合物包括：(a)至少一种聚二甲基硅氧烷、氟代聚二甲基硅氧烷或二者的组合物，其包含具有至少两个羟基硅基的反应性硅烷官能团；(b)至少一种聚二甲基硅氧烷、氟代聚二甲基硅氧烷或二者的组合物，其包含具有至少两个氢硅基的反应性硅烷官能团；以及(c)至少一种光致活性组分，当暴露于辐射下时，会产生从氨基化合物、胍化合物、磷氮化合物、脲基磷杂环丙烷和它们的组合物中选择的至少一种碱；其中，组分(a)和/或(b)中至少有一种的平均反应性硅烷官能团为至少三个。
• CURABLE COMPOSITION COMPRISING DUAL REACTIVE SILANE FUNCTIONALITY
  申请人：Yang Yu

  公开号：US20130102728A1

  公开（公告）日：2013-04-25

  A curable composition comprises (a) at least one inorganic or organic compound comprising reactive silane functionality comprising at least one hydrosilyl moiety; (b) at least one inorganic or organic compound comprising reactive silane functionality comprising at least one hydroxysilyl moiety, the hydroxysilyl moiety optionally being generated in situ by hydrolysis of at least one hydrosilyl moiety; and (c) at least one base selected from amidines, guanidines, phosphazenes, proazaphosphatranes, and combinations thereof; with the proviso that, when component (a) is an organic polymer, then component (b) is different from component (a) and is not generated in situ by hydrolysis of component (a).

  一种可治愈的组合物包括：（a）至少一种含有反应性硅烷官能团的无机或有机化合物，其中该反应性硅烷官能团包括至少一个氢硅烷基；（b）至少一种含有反应性硅烷官能团的无机或有机化合物，其中该反应性硅烷官能团包括至少一个羟基硅烷基，该羟基硅烷基可以通过至少一个氢硅烷基的水解而在原位生成；以及（c）选自氨基甲酸酰胺、鸟氨酸、磷氮化物、丙磺酰膦杂环戊烷和其组合物中的至少一种碱，但当组分（a）为有机聚合物时，则组分（b）与组分（a）不同且不是通过组分（a）的水解在原位生成的。
• CURABLE COMPOSITION
  申请人：Matsushita Noriko

  公开号：US20090171025A1

  公开（公告）日：2009-07-02

  The present invention has its object to provide, by using a non-organotin curing catalyst, a curable composition having a practical level of curability. Furthermore, the present invention has its object to provide a curable composition excellent in adhesiveness while it secures a practical level of curability. The present invention relates to a curable composition which comprises: (A) an organic polymer containing a silicon-containing group capable of crosslinking by siloxane bond formation and (B) a silanol condensation catalyst: and that the silanol condensation catalyst is an amine compound and that an aqueous solution prepared by adding 5 millimoles of the amine compound to 100 g of a mixed solvent composed of isopropyl alcohol and water in a weight ratio of 10:3 has a pH value of not lower than 13.4 as measured at 23° C. according to JIS Z 8802.

  本发明的目的是提供一种可固化组合物，使用非有机锡固化催化剂，具有实用的固化水平。此外，本发明的目的是提供一种优异的粘附性可固化组合物，同时保证实用的固化水平。本发明涉及一种可固化组合物，其包括：（A）含有硅含基的有机聚合物，能够通过硅氧烷键形成交联，以及（B）硅醇缩合催化剂；所述硅醇缩合催化剂是胺化合物，并且将5毫摩尔的胺化合物加入到由异丙醇和水按重量比10:3组成的混合溶剂100克中制备的水溶液，在23℃下按照JIS Z 8802测量，其pH值不低于13.4。