Benzenemethanamine, 4-(2-propen-1-yl)- | 1823835-84-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzenemethanamine, 4-(2-propen-1-yl)-
• 英文别名: (4-prop-2-enylphenyl)methanamine
• CAS: 1823835-84-2
• 化学式: C₁₀H₁₃N
• 分子量: 147.22
• InChiKey: PQKZGMDXRHORSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-氧代-2-丁酸甲酯 、 Benzenemethanamine, 4-(2-propen-1-yl)- 以 氯仿 为溶剂， 反应 5.0h， 以100%的产率得到
  参考文献：
  名称：

  Efficient synthesis of 2,6,9-triazabicyclo[3.3.1]nonanes through amine-mediated formal [4+4] reaction of unsaturated imines

  摘要：

  Formal [4+4] reaction of the unsaturated benzyl- or allylimines, which is efficiently mediated by primary amine, provides the 2,6,9-triazabicyclo[3.3.1]nonane derivatives. Variously substituted homo- and hetero-coupling products are obtained in good to excellent yields by quite a simple procedure under mild conditions: by mixing the unsaturated aldehydes with the amines at room temperature. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.08.081

文献信息

• Non-steroidal progesterone receptor modulators
  申请人：SCHWEDE Wolfgang

  公开号：US20090270381A1

  公开（公告）日：2009-10-29

  The present invention relates to non-steroidal progesterone receptor modulators of the general formula I, the use of the progesterone receptor modulators for the manufacture of medicaments, and pharmaceutical compositions which comprise these compounds. The compounds according to the invention are suitable for the therapy and prophylaxis of gynecological disorders such as endometriosis, leiomyomas of the uterus, dysfunctional bleeding and dysmenorrhoea, and for the therapy and prophylaxis of hormone-dependent tumours and for use for female fertility control and for hormone replacement therapy.

  本发明涉及一般式I的非类固醇孕激素受体调节剂，以及利用这些孕激素受体调节剂制造药物和包含这些化合物的药物组合物。根据本发明的化合物适用于治疗和预防妇科疾病，如子宫内膜异位症、子宫平滑肌瘤、功能性出血和月经痛，并用于激素依赖性肿瘤的治疗和预防，以及用于女性生育控制和激素替代疗法。
• Production of mixed acid anhydride and amide compound
  申请人：SUMITOMO CHEMICAL CO., LTD.

  公开号：US20020032346A1

  公开（公告）日：2002-03-14

  There is disclosed an advantageous mixed acid anhydride production method of formula (1): R 1 C(O)OY(O) n (R 2 ) p (1) wherein R 1 , R 2 and Y denote the same as defined below, n and p denote an integer of 1 or 2, which is characterized by adding a carboxylic acid of formula (2); R 1 COOH  (2) wherein R 1 denotes a hydrogen atom, an optionally substituted alkyl group or the like, an organic base to a solution of a carboxylic acid activating agent of formula (3); (R 2 ) p Y(O) n X  (3) wherein R 2 denotes an optionally substituted aliphatic hydrocarbyl group or the like, Y denotes a carbon atom, a phosphorus atom, or a sulfur atom, and X denotes a chlorine atom or the like.

  公开了一种有利的混合酸酐生产方法，其化学式为（1）：R1C（O）OY（O）n（R2）p（1）其中R1、R2和Y的定义如下，n和p表示为1或2的整数，其特征在于向化学式（2）的羧酸中加入一个羧酸活化剂的有机碱；R1COOH（2）其中R1表示氢原子、可选择取代的烷基或类似物，有机碱加入到化学式（3）的羧酸活化剂溶液中；（R2）pY（O）nX（3）其中R2表示可选择取代的脂肪烃基或类似物，Y表示碳原子、磷原子或硫原子，X表示氯原子或类似物。
• Derivatives of 2-arylimino-2,3-dihydrothiazoles, their preparation processes and their therapeutic use
  申请人：Moinet Christophe

  公开号：US20070043095A1

  公开（公告）日：2007-02-22

  The present invention is drawn to compounds of the formula in racemic and enantiomeric form or all combinations of these forms wherein the various substituents are as defined in the application which compounds have a good affinity for certain subtypes of somatostatin receptors and have useful pharmacological properties.

  本发明涉及公式中的化合物，包括外消旋和对映体形式或这些形式的所有组合，其中各种取代基的定义如申请书所述。这些化合物对某些生长抑素受体亚型具有良好的亲和力，并具有有用的药理学性质。
• Photocrosslinkable polyimide ammonia salts
  申请人：OCCIDENTAL CHEMICAL CORPORATION

  公开号：EP0547555A2

  公开（公告）日：1993-06-23

  Disclosed is a polyimide ammonium salt comprising the reaction product of an ethylenically unsaturated amine with an aromatic polyimide having pendant carboxylic acid groups, said polyimide comprising the reaction product of diamine and aromatic dianhydride, where the diamine comprises an aromatic carboxylic acid diamine having at least one carboxylic acid. A substrate can be coated with the polyimide ammonium salt by forming a composition of a crosslinking agent and a solution of the polyimide salt in an organic solvent, spreading the composition on the substrate, evaporating the solvent to form a coating, exposing at least some of the coating to actinic radiation to crosslink and insolubilize the exposed portions of the coating, and washing the unexposed portions away by dissolving them in an organic solvent.

  本发明公开了一种聚酰亚胺铵盐，包括乙烯不饱和胺与具有悬垂羧酸基团的芳香族聚酰亚胺的反应产物，所述聚酰亚胺包括二胺和芳香族二酐的反应产物，其中二胺包括具有至少一种羧酸的芳香族羧酸二胺。可以通过以下方法在基材上涂覆聚酰亚胺铵盐：将交联剂和聚酰亚胺盐溶液在有机溶剂中配制成组合物，将组合物涂在基材上，蒸发溶剂形成涂层，将至少部分涂层暴露在光辐射下，使涂层的暴露部分交联和不溶解，然后将未暴露部分溶解在有机溶剂中洗掉。
• Production of mixed acid anhydride and amine compound
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1160236A2

  公开（公告）日：2001-12-05

  There is disclosed an advantageous method for producing a mixed acid anhydride of formula (1):         R1C(O)OY(O)n(R2)p     (1) wherein R1, R2 and Y denote the same as defined below, and n and p denote an integer of 1 or 2, which is characterized by adding a carboxylic acid of formula (2):         R1COOH     (2) wherein R1 denotes a hydrogen atom, an optionally substituted alkyl group or the like, and an organic base to a solution of a carboxylic acid activating agent of formula (3):         (R2)pY(O)nX     (3) wherein R2 denotes an optionally substituted aliphatic hydrocarbyl group or the like, Y denotes a carbon atom, a phosphorus atom, or a sulfur atom, and X denotes a chlorine atom or the like.

  本发明公开了一种生产式（1）混合酸酐的有效方法： R1C(O)OY(O)n(R2)p (1) 其中 R1、R2 和 Y 表示与下文定义相同，n 和 p 表示 1 或 2 的整数，其特征在于加入了式 (2) 的羧酸： R1COOH (2) 其中 R1 表示氢原子、任选取代的烷基或类似基团，以及一种有机碱： (R2)pY(O)nX (3) 其中 R2 表示任选取代的脂肪族烃基或类似基团，Y 表示碳原子、磷原子或硫原子，X 表示氯原子或类似基团。