申请人:SurModics, Inc
公开号:US20030215419A1
公开(公告)日:2003-11-20
A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
一种用于钝化生物材料表面的试剂及相关方法,该试剂包括一个潜伏反应基团和一个双官能团脂肪族酸(如脂肪酸),以及一个间隔基团,该间隔基团以保留每个基团所需功能的方式将潜伏反应基团与脂肪族酸连接起来。一旦通过潜伏反应基团与表面结合,试剂就能以足以保持白蛋白并使其定向的方式(如浓度和定向)将脂肪族酸呈现在体内的生理环境中。