An on-spot selectively activated hydrophobic slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic material and a compound bearing a functional group protected by a protecting group, wherein the functional group is imide or cyclic amide, and the protecting group is a photo acid group such as a tosyloxy group. The hydrophobic copolymer coated on a substrate is then subjected to selective photolithographical activation so that the slide will have functional active copolymer spots separated by inactive copolymers. The resulting slide is suitable for the preparation of high-density and high-efficiency bio-chip/microarray.
一种现场选择性激活的疏
水性载玻片/微阵列。该制备方法涉及一种疏
水性共聚物,其制备方法是将疏
水性材料与带有受保护基团保护的官能团的化合物进行混合、接枝或共聚,其中官能团为
酰亚胺或环酰胺,保护基团为对
甲苯磺酰氧基等光酸基团。然后将涂布在基底上的疏
水共聚物进行选择性光刻活化,使载玻片上的功能性活性共聚物点被非活性共聚物隔开。这样制成的载玻片适用于制备高密度、高效率的
生物芯片/微阵列。