申请人:——
公开号:US20030073845A1
公开(公告)日:2003-04-17
This invention is directed to sulfonyl aromatic hydroxamic acid compounds and salts thereof that, inter alia, inhibit matrix metalloprotease (MMP) activity and/or aggrecanase activity. In some particularly preferred embodiments, the compound corresponds in structure to one of the following formulas:
1
wherein W
2
, the R groups, and —A—R—E—Y are described in more detail in Applicants' specification. This invention also is directed to a process that comprises administering such a compound or pharmaceutically acceptable salt thereof to a host animal having a condition associated with MMP activity.
本发明涉及磺酰基芳基羟肟酸化合物及其盐,这些化合物在抑制基质金属蛋白酶(MMP)活性和/或聚集素酶活性方面具有作用。在一些特别优选的实施方式中,该化合物的结构符合以下公式之一:其中W2、R基团和—A—R—E—Y在申请人的说明书中有更详细的描述。本发明还涉及一种过程,该过程包括向患有与MMP活性相关的病况的宿主动物施用这种化合物或其药用可接受盐。