2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-1-phenylpyrazolidin-3-one | 403983-70-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-1-phenylpyrazolidin-3-one
• CAS: 403983-70-0
• 化学式: C16H11F3N4O5
• 分子量: 396.28
• InChiKey: SUNPSNFIWYZGOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  115
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• Substituted hydrazine derivatives
  申请人：——

  公开号：US20020120149A1

  公开（公告）日：2002-08-29

  A method for the inhibition of high affinity glycine transporters, compounds that inhibit these transporters; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of disease states in which glycine is involved are disclosed.

  本发明公开了一种抑制高亲和性甘氨酸转运体的方法、抑制这些转运体的化合物；包含此类化合物的药用活性组合物；以及此类化合物的上述用途或在控制或预防涉及甘氨酸的疾病状态的制剂中的用途。
• SUBSTITUTED HYDRAZINE DERIVATIVES
  申请人：Gliatech, Inc.

  公开号：EP1318802A2

  公开（公告）日：2003-06-18
• US7049343B2
  申请人：——

  公开号：US7049343B2

  公开（公告）日：2006-05-23
• [EN] SUBSTITUTED HYDRAZINE DERIVATIVES<br/>[FR] DERIVES HYDRAZINIQUES SUBSTITUES
  申请人：GLIATECH INC

  公开号：WO2002019967A2

  公开（公告）日：2002-03-14

  A method for the inhibition of high affinity glycine transporters, compounds that inhibit these transporters; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of disease states in which glycine is involved are disclosed.