2-(Bis{2-[(4-benzoylphenyl)methoxy]ethyl}amino)ethane-1-sulfonic acid | 557504-55-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(Bis{2-[(4-benzoylphenyl)methoxy]ethyl}amino)ethane-1-sulfonic acid
• 英文别名: 2-[bis[2-[(4-benzoylphenyl)methoxy]ethyl]amino]ethanesulfonic acid
• CAS: 557504-55-9
• 化学式: C₃₄H₃₅NO₇S
• 分子量: 601.7
• InChiKey: NRTABCXMDFHEGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  43
• 可旋转键数：
  17
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  119
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Tissue graft materials containing biocompatible agent and methods of making and using same
  申请人：Stucke Sean M.

  公开号：US20080063627A1

  公开（公告）日：2008-03-13

  The invention provides implantable tissue graft materials composed of a collagenous tissue scaffold and a biocompatible agent bonded to the tissue scaffold via an activated photoreactive group. The invention further provides methods including steps of obtaining a tissue graft material comprising a collagenous tissue scaffold; contacting the collagenous tissue scaffold with a biocompatible agent composition that includes biocompatible agent and one or more photoreactive groups; and treating the collagenous tissue scaffold and biocompatible agent composition to activate the photoreactive groups and bond the biocompatible agent to the tissue scaffold via one or more activated photoreactive groups. Implantable prostheses formed of the tissue graft material are also contemplated.

  该发明提供了由胶原组织支架和通过活化光反应基团与组织支架结合的生物相容剂组成的可植入组织移植材料。该发明还提供了包括以下步骤的方法：获得包括胶原组织支架的组织移植材料；将胶原组织支架与包括生物相容剂和一个或多个光反应基团的生物相容剂组成物接触；并处理胶原组织支架和生物相容剂组成物以激活光反应基团并通过一个或多个活化光反应基团将生物相容剂与组织支架结合。还可以考虑由该组织移植材料形成的可植入假体。
• STILBENE-BASED REACTIVE COMPOUNDS, POLYMERIC MATRICES FORMED THEREFROM, AND ARTICLES VISUALIZABLE BY FLUORESCENCE
  申请人：SurModics, Inc.

  公开号：US20140162083A1

  公开（公告）日：2014-06-12

  The invention is directed to latent reactive and polymerizable derivatives of fluorescent stilbene-based compounds. The compounds can be used to provide articles with a fluorescence property, such as medical devices (e.g., catheters). The fluorescent compounds can be used in association with polymers, or can be incorporated into polymers, and the polymers used in a coating composition on the article surface. The compounds allow for visual or machine inspection of coating properties such as uniformity of coverage.

  这项发明涉及荧光基苯乙烯化合物的潜在反应性和聚合物化衍生物。这些化合物可用于赋予物品荧光特性，例如医疗器械（如导管）。荧光化合物可与聚合物结合使用，或者可以被纳入聚合物中，并且聚合物可用作涂层组合物涂覆在物品表面。这些化合物允许对涂层性能进行目视或机器检查，比如涂层覆盖的均匀性。
• COATING AGENTS AND COATED ARTICLES
  申请人：Wen Jie

  公开号：US20120258313A1

  公开（公告）日：2012-10-11

  The invention describes novel coating agents that include a polymer, one or more latent reactive groups and one or more noncovalent linking groups, the noncovalent linking groups selected to interact with a substrate to which the coating agent is applied. The coating agents are useful for providing a coating that can be further functionalized (for example, by application of additional coating layers), or for providing desirable properties to a surface.

  这项发明描述了一种新型的涂层剂，包括一个聚合物、一个或多个潜在的反应基团和一个或多个非共价连接基团，所述非共价连接基团被选择用于与涂层剂所施加的基底相互作用。这些涂层剂可用于提供可进一步功能化的涂层（例如，通过施加额外的涂层层），或为表面提供理想的特性。
• Insertable medical devices having microparticulate-associated elastic substrates and methods for drug delivery
  申请人：SurModics, Inc.

  公开号：EP2689789A1

  公开（公告）日：2014-01-29

  The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic surfaces the microparticulates can be released to a subject.

  本发明提供的可插入式医疗器械具有与含生物活性剂的微粒子和涂层材料相关的弹性表面。弹性表面膨胀后，微粒子可释放给受试者。
• Article coatings including oligomerized polyphenol layer and biological methods of use
  申请人：SURMODICS, INC.

  公开号：US10201637B2

  公开（公告）日：2019-02-12

  Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological molecule.

  本公开的实施方案包括包含低聚多酚层的涂层。低聚多酚层可用作医疗设备上的中间涂层，与合成或天然聚合物氢键结合，而合成或天然聚合物又可用作面层或与另一涂层进一步结合。多层涂层可提供血液相容性或润滑性等特性。在其他实施方案中，低聚多酚层被用作医疗设备的止血层，可与血液接触并促进凝血。低聚多酚层还可用于医疗设备的内表面（如内径），以防止细菌附着。低聚多酚层还可用于体外诊断物品或细胞培养装置的表面，以促进生物分子的吸附。