1-[(Z)-thiophen-2-ylmethylideneamino]-3-[(E)-thiophen-2-ylmethylideneamino]thiourea | 6956-32-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 1-[(Z)-thiophen-2-ylmethylideneamino]-3-[(E)-thiophen-2-ylmethylideneamino]thiourea
• CAS: 6956-32-7
• 化学式: C₁₁H₁₀N₄S₃
• 分子量: 294.4
• InChiKey: NLVSQWCSDRRMRQ-HAKHBUOSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  137
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] ACTIVATORS OF KLF14 AND USES THEREOF<br/>[FR] ACTIVATEURS DE KLF14 ET LEURS UTILISATIONS
  申请人：UNIV MICHIGAN REGENTS

  公开号：WO2017044607A1

  公开（公告）日：2017-03-16

  The present invention provides compositions enhancing reverse cholesterol transport through increasing HDL-C and ApoA-1 levels and enhancing cholesterol efflux, and related methods of treating and/or preventing cardiovascular disease (e.g., atherosclerosis, dyslipidemia, hypercholesterolemia and inflammation). In particular, the invention relates to compositions capable of increasing KLF14 activity for purposes of increasing levels and functions of HDL-C and ApoA-1 and cholesterol efflux in macrophage, and as a result, enhancing reverse cholesterol transport.