2-(1-piperidinomethylidene)-N-3-chlorophenylsuccinimide | 140867-10-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-(1-piperidinomethylidene)-N-3-chlorophenylsuccinimide
• 英文别名: (3Z)-1-(3-chlorophenyl)-3-(piperidin-1-ylmethylidene)pyrrolidine-2,5-dione
• CAS: 140867-10-3
• 化学式: C₁₆H₁₇ClN₂O₂
• 分子量: 304.776
• InChiKey: YZQSJMMGQDRLOX-QXMHVHEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  哌啶 、 5-(3-chlorophenyl)-1-oxa-5-azaspiro<2.4>heptane-4,6-dione 以 乙醇 为溶剂， 以28%的产率得到2-(1-piperidinomethylidene)-N-3-chlorophenylsuccinimide
  参考文献：
  名称：

  Transformations starting from biotechnologically available materials, part 2: First example of a direct conversion of spirooxiranes into enamines

  摘要：

  An unpredecent formation of enamines in the reaction of 5-aryl-1-oxa-5-azaspiro[2.4]heptane-4,6-diones with morpholine and piperidine is reported. The transformations proceed via corresponding beta-aminoalcohols which were detected by C-13-NMR.

  DOI：

  10.1007/bf01045307

文献信息

• Transformations starting from biotechnologically available materials, part 2: First example of a direct conversion of spirooxiranes into enamines
  作者：Jan Světlík

  DOI：10.1007/bf01045307

  日期：1992.1

  An unpredecent formation of enamines in the reaction of 5-aryl-1-oxa-5-azaspiro[2.4]heptane-4,6-diones with morpholine and piperidine is reported. The transformations proceed via corresponding beta-aminoalcohols which were detected by C-13-NMR.