tert-butyl N-[2-(1-hydroxy-2,2-diphenylethyl)-6-methyl-5,7-dioxo-4a,7a-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl]carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl N-[2-(1-hydroxy-2,2-diphenylethyl)-6-methyl-5,7-dioxo-4a,7a-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl]carbamate
• 化学式: C₂₇H₃₁N₃O₅
• 分子量: 477.6
• InChiKey: ZTRBIAPRDKBALH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  99.2
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• IMIDOPIPERIDINE COMPOUNDS AS INHIBITORS OF HUMAN POLYNUCLEOTIDE KINASE PHOSPHATASE
  申请人：THE GOVERNORS OF THE UNIVERSITY OF ALBERTA

  公开号：US20200148675A1

  公开（公告）日：2020-05-14

  There is described herein imidopiperidine compounds as inhibitors of human polynucleotide kinase phosphatase.

  本文描述了咪唑哌啶化合物作为人类多核苷酸激酶磷酸酶的抑制剂。
• Synthetic lethality in cancer
  申请人：The Governors of the University of Alberta

  公开号：US10087448B2

  公开（公告）日：2018-10-02

  There is described herein compounds, compositions and methods for inducing synthetic lethality in a cancer cell(s).

  本文描述了诱导癌细胞合成致死的化合物、组合物和方法。
• Imidopiperidine compounds as inhibitors of human polynucleotide kinase phosphatase
  申请人：THE GOVERNORS OF THE UNIVERSITY OF ALBERTA

  公开号：US11325905B2

  公开（公告）日：2022-05-10

  There is described herein imidopiperidine compounds as inhibitors of human polynucleotide kinase phosphatase.

  本文描述了作为人类多核苷酸激酶磷酸化酶抑制剂的亚胺基哌啶化合物。
• SYNTHETIC LETHALITY IN CANCER
  申请人：The Governors of the University of Alberta

  公开号：EP2635579B1

  公开（公告）日：2020-11-25
• SMALL MOLECULE INHIBITORS OF POLYNUCLEOTIDE KINASE/PHOSPHATASE, POLY(ADP-RIBOSE) POLYMERASE AND USES THEREOF
  申请人：Weinfeld Michael

  公开号：US20120142721A1

  公开（公告）日：2012-06-07

  The present invention generally relates to use of compounds and compositions as a chemosensitizers and/or radiosensitizers and/or inhibitors of PNKP phosphatase activity. The present invention provides pharmaceutical combinations and/or a pharmaceutically acceptable salt thereof, kits containing such compounds and/composition and methods of using such compounds and/or compositions.