Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use
申请人:——
公开号:US20030114499A1
公开(公告)日:2003-06-19
This invention encompasses anthranilamides with heteroarylsulfonyl side chain, process for their preparation, their use as medicament or diagnostic aid, and pharmaceutical preparations containing them. Compounds of formula I,
1
in which R1 to R7 have the meanings stated in the claims, act on the Kv1.5 potassium channel and inhibit a potassium current which is referred to as the ultra-rapidly activating delayed rectifier in the atrium of the human heart. They are therefore suitable as novel antiarrhythmic ingredients, such as for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutter.
这项发明涵盖了具有杂环磺酰基侧链的蒽酰胺,其制备方法,它们作为药物或诊断辅助剂的用途,以及含有它们的制药制剂。具有式I的化合物,在其中R1至R7具有权利要求中所述的含义,作用于Kv1.5钾通道,并抑制被称为人类心房中超快速激活延迟整流器的钾电流。因此,它们适用作为新型抗心律失常成分,例如用于治疗和预防心房心律失常,如心房颤动(AF)或心房扑动。