申请人:Richard E. Robert
公开号:US20060165753A1
公开(公告)日:2006-07-27
According to one aspect, implantable or insertable medical devices are provided, which contain polymeric release regions that release one or more therapeutic agents. The polymeric release regions, in turn, contain the following: (i) a first bonding polymer having a first polymer block and a first bonding group and (ii) a second bonding polymer having a second polymer block and a second bonding group. A therapeutic agent is disposed beneath or within the polymeric release region. The first and second polymer blocks can be the same as or different from one another, as can the first and second bonding groups. The first and second bonding groups are bound to one another via non-covalent bonding, for example, via electrostatic interaction, coordinative bonds, π-π stacking, or hydrogen bonding. According to another aspect, implantable or insertable medical devices are provided, which have a polymeric region that comprises (a) a first polymer having a first polymer block and a first bonding group and (b) a therapeutic agent having a bonding group that bonds to said first bonding group via non-covalent bonding at ambient temperature.
根据一个方面,提供了可植入或可插入的医疗器械,其中包含可释放一种或多种治疗剂的聚合物释放区。这些聚合物释放区又包含以下部分:(i) 具有第一聚合物嵌段和第一键合基团的第一键合聚合物和 (ii) 具有第二聚合物嵌段和第二键合基团的第二键合聚合物。治疗剂置于聚合物释放区域的下方或内部。第一和第二聚合物块可以彼此相同或不同,第一和第二键合基团也可以彼此不同。第一和第二结合基团通过非共价键结合在一起,例如通过静电作用、配位键、π-π堆积或氢键。根据另一个方面,提供了可植入或插入式医疗器械,其聚合物区域包括:(a) 具有第一聚合物嵌段和第一键合基团的第一聚合物;(b) 具有键合基团的治疗剂,该键合基团在环境温度下通过非共价键合与所述第一键合基团结合。