Ethyl 5-[3-(2-hydroxyethylamino)-3-oxopropyl]-7-methoxy-2-phenyl-1-benzofuran-3-carboxylate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: Ethyl 5-[3-(2-hydroxyethylamino)-3-oxopropyl]-7-methoxy-2-phenyl-1-benzofuran-3-carboxylate
• 化学式: C₂₃H₂₅NO₆
• 分子量: 411.4
• InChiKey: JXBYIZUJKGKPEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  30
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  98
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Stat modulators
  申请人：Frank David A.

  公开号：US20110144043A1

  公开（公告）日：2011-06-16

  The present invention is directed to methods, kits and compositions for modulating the activity of Stat molecules (e.g., Stat1, Stat3 and Stat5). The compounds of the invention are useful for treating and/or preventing disorders characterized by Stat dysregulation, such as hyperproliferative disorders. Further, the compounds of the present invention are also useful in culturing stem cells and treating ischemic disorders.
• US8445517B2
  申请人：——

  公开号：US8445517B2

  公开（公告）日：2013-05-21