4-(1,1-Dimethylethyl)-1,2-diethoxybenzene | 226555-37-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(1,1-Dimethylethyl)-1,2-diethoxybenzene
• 英文别名: 4-tert-butyl-1,2-diethoxybenzene
• CAS: 226555-37-9
• 化学式: C₁₄H₂₂O₂
• 分子量: 222.32
• InChiKey: ONEHAPZYTRVOID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• CYSTEINE PROTEASE INHIBITORS
  申请人：Unoki Gen

  公开号：US20090291945A1

  公开（公告）日：2009-11-26

  To provide a compound having an excellent cysteine protease inhibitory effect, and to provide a drug for treatment or prevention of the disease selected from the group consisting of osteoporosis, osteoarthritis, chronic rheumatoid arthritis, Paget's disease of bone, hypercalcemia, bone metastasis of cancer, and ostealgia. A compound represented by formula (1) or a pharmaceutically acceptable salt thereof, or a drug or pharmaceutical composition containing the same as an effective component.

  提供一种具有优异半胱氨酸蛋白酶抑制作用的化合物，并提供一种用于治疗或预防骨质疏松症、骨关节炎、慢性类风湿性关节炎、骨Paget病、高钙血症、骨癌转移和骨痛的药物。化合物由式（1）表示，或其药学上可接受的盐，或将其作为有效成分的药物或药物组合物。
• Dialkoxybenzene electron donors
  申请人：UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION

  公开号：EP0926119A1

  公开（公告）日：1999-06-30

  Novel compounds of the structure wherein R1 and R2 are each an alkoxy group which may be the same or different and have from one to ten carbon atoms, and R3-R6 are each individually, hydrogen, a hydrocarbyl group, a hydrocarboxyl group, a nitro group, a silyl group or a halogen, with the provisos that (1) if either R1 and R2 are methoxy, then at least one of R3-R6 is not hydrogen, (2) if R1 and R2 are both ethoxy, then at least one of R3-R6 is not hydrogen, and (3) R1 and R2 cannot both be methoxy. These electron donor compounds are used in the manufacture of olefin polymerization catalysts.

  结构如下的新型化合物 其中 R1 和 R2 各为烷氧基，可以相同或不同，具有一至十个碳原子，R3-R6 各为单独的氢、烃基、烃基、硝基、硅基或卤素，但条件是：(1) 如果 R1 和 R2 都是甲氧基，则 R3-R6 中至少有一个不是氢；(2) 如果 R1 和 R2 都是乙氧基，则 R3-R6 中至少有一个不是氢；(3) R1 和 R2 不能都是甲氧基。这些电子供体化合物用于制造烯烃聚合催化剂。
• Novel electron donor containing compositions
  申请人：UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION

  公开号：EP0922712A1

  公开（公告）日：1999-06-16

  An olefin polymerization catalyst having an electron donor of a 1,2 dialkoxy benzene, wherein at least one alkoxy group has at least two carbon atoms, and the use and manufacture of the catalyst are taught by the present invention.

  本发明教导了一种烯烃聚合催化剂，其电子供体为 1,2-二烷氧基苯，其中至少一个烷氧基具有至少两个碳原子，本发明还教导了催化剂的使用和制造方法。
• Vinblastine 20″ amides: synthetic analogs that maintain or improve potency and simultaneously overcome Pgp-derived efflux and resistance
  申请人：The Scripps Research Institute

  公开号：US10689381B2

  公开（公告）日：2020-06-23

  A vinca alkaloid compound substituted at the 20′-position with a carboxamido group is disclosed. The carbonyl of the carboxamido group is bonded to a 20′-amino group and to a ring system that contains up to three 5-, 6- or 7-membered rings that are fused or otherwise bonded together. Each ring can be carbocyclic or heterocyclic, with a heterocyclic ring containing up to three hetero ring atoms that are the same or different and are selected from nitrogen, oxygen and sulfur. The ring system can include up to four substituent groups other than hydrogen that are discussed within. Methods of preparing the compounds are disclosed as are compositions for their use and methods of treatment using d compound. A particularly preferred compound has an activity in specified cancer cell growth inhibition assays that is the same or better than its parental, unsubstituted vinca compound and is not subject to Pgp-mediated efflux.

  本发明公开了一种在 20′位被羧酰胺基取代的长春花生物碱化合物。羧酰胺基团的羰基与 20′-氨基基团和一个环系统键合，该环系统包含最多三个融合或以其他方式键合在一起的 5、6 或 7 元环。每个环可以是碳环或杂环，其中杂环含有最多三个相同或不同的杂环原子，这些原子选自氮、氧和硫。除氢外，该环系还可包括多达四个取代基团。公开了制备化合物的方法以及使用这些化合物的组合物和使用 d 化合物进行治疗的方法。一种特别优选的化合物在特定癌细胞生长抑制实验中的活性与其亲本未取代的长春花化合物相同或更好，并且不受 Pgp 介导的外流影响。
• SELF-LIMITING CATALYST COMPOSITION WITH BIDENTATE INTERNAL DONOR
  申请人：Dow Global Technologies Inc.

  公开号：EP2225288A1

  公开（公告）日：2010-09-08