3,3',4,5'-Tetrachlorosalicylanilide | 34262-92-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3',4,5'-Tetrachlorosalicylanilide
• 英文别名: 3,4-dichloro-N-(3,5-dichlorophenyl)-2-hydroxybenzamide
• CAS: 34262-92-5
• 化学式: C₁₃H₇Cl₄NO₂
• 分子量: 351.0
• InChiKey: ZJIQNOMMMRNUEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Dentifrice compositions
  申请人：UNILEVER PLC

  公开号：EP0161898A2

  公开（公告）日：1985-11-21

  It is disclosed that a dentifrice which includes a surfactant and an anti-plaque agent comprising a substantially water--insoluble non-cationic antimicrobial agent or a zinc salt or a mixture thereof has enhanced activity when the dentifrice comprises at least 0.2% by weight of a lamellar liquid crystal surfactant phase having a lamellar spacing of less than 6.0 nm.

  据公开，当牙膏中含有至少 0.2% （按重量计）的片状液晶表面活性剂相（其片状间距小于 6.0 nm）时，牙膏的活性增强，该牙膏包括表面活性剂和抗牙菌斑剂，抗牙菌斑剂包括基本上不溶于水的非阳离子抗菌剂或锌盐或它们的混合物。
• Anti-calculus toothpaste compositions having improved shelf-life
  申请人：Beecham Inc.

  公开号：EP0397452A2

  公开（公告）日：1990-11-14

  The problem of providing a storage stable anti-calculus toothpaste comprising a tripolyphosphate salt is remedied by incorporating more than 4% of the salt and having the pH from about 8 to about 10. A tripoly­phosphate salt may also be combined with a noncationic anti-bacterial agent such as triclosan to provide a composition having anti-calculus and anti-plaque activity.

  通过加入 4% 以上的三聚磷酸盐，并将 pH 值控制在约 8 到约 10 之间，可以解决含有三聚磷酸盐的抗牙结石牙膏的储存稳定性问题。三聚磷酸盐还可与三氯生等非阳离子抗菌剂结合使用，以提供具有抗牙结石和抗牙菌斑活性的组合物。
• Dentrifice compositions having reduced abrasivity
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1203574A2

  公开（公告）日：2002-05-08

  A method for reducing an abrasivity of a dentifrice composition containing an abrasive, includes incorporating into the dentifrice composition a zinc salt in an amount sufficient to reduce a dentinal abrasivity of the composition by at least 10% and reduce an enamel abrasivity of the dentifrice composition by at least 10%. The method provides an improved dentifrice composition, which is at least 90% as effective at stain removal as the original dentifrice composition. Suitable zinc salts include, e.g., zinc citrate, zinc chloride, zinc acetate, zinc oxide and zinc sulfate. Suitable abrasives include, e.g., silica, alumina and alkali metal meta-phosphates.

  一种降低含磨料的牙膏组合物磨蚀性的方法，包括在牙膏组合物中加入锌盐，加入量足以将组合物的牙本质磨蚀性降低至少 10%，并将牙膏组合物的珐琅质磨蚀性降低至少 10%。该方法提供了一种改进的牙膏组合物，其去渍效果至少是原始牙膏组合物的 90%。合适的锌盐包括柠檬酸锌、氯化锌、醋酸锌、氧化锌和硫酸锌等。合适的研磨剂包括二氧化硅、氧化铝和碱金属偏磷酸盐等。
• Tooth whitening composition and method employing dicarboxylic acid whitening agent
  申请人：——

  公开号：US20020061282A1

  公开（公告）日：2002-05-23

  A tooth-whitening composition includes at least one dicarboxylic acid, such as oxalic acid malonic acid, tartaric acid, and/or a salt thereof as a whitening agent, and preferably contains the essential oils thymol; methyl salicylate; menthol; and eucalyptol. The composition can be provided in a variety of forms, including a mouthwash, a toothpaste, a tooth gel, a tooth powder, an oral film and a lozenge. The composition is effective for whitening teeth by removing extrinsic stains from external surfaces of the teeth. The composition also helps to maintain the teeth white by hindering the deposition of extrinsic stains on the external surfaces of teeth.

  一种牙齿美白组合物包括至少一种二羧酸，如草酸丙二酸、酒石酸和/或其盐作为美白剂，最好还含有百里酚、水杨酸甲酯、薄荷醇和桉叶油精油。该组合物可以多种形式提供，包括漱口水、牙膏、牙凝胶、牙粉、口腔薄膜和锭剂。该组合物能有效去除牙齿外表面的外源性污渍，从而美白牙齿。该组合物还能阻止外源性污渍在牙齿外表面沉积，从而有助于保持牙齿洁白。
• Dentifrice compositions having reduced abrasivity
  申请人：——

  公开号：US20030026768A1

  公开（公告）日：2003-02-06

  A method for reducing an abrasivity of a dentifrice composition containing an abrasive, includes incorporating into the dentifrice composition a zinc salt in an amount sufficient to reduce a dentinal abrasivity of the composition by at least 10% and reduce an enamel abrasivity of the dentifrice composition by at least 10%. The method provides an improved dentifrice composition, which is at least 90% as effective at stain removal as the original dentifrice composition. Suitable zinc salts include, e.g., zinc citrate, zinc chloride, zinc acetate, zinc oxide and zinc sulfate. Suitable abrasives include, e.g., silica, alumina and alkali metal meta-phosphates.

  一种降低含磨料的牙膏组合物磨蚀性的方法，包括在牙膏组合物中加入锌盐，加入量足以将组合物的牙本质磨蚀性降低至少 10%，并将牙膏组合物的珐琅质磨蚀性降低至少 10%。该方法提供了一种改进的牙膏组合物，其去渍效果至少是原始牙膏组合物的 90%。合适的锌盐包括柠檬酸锌、氯化锌、醋酸锌、氧化锌和硫酸锌等。合适的研磨剂包括二氧化硅、氧化铝和碱金属偏磷酸盐等。