2-(4,6-dimethyl-3-oxo-[1,2]thiazolo[5,4-b]pyridin-2-yl)-N-[(4-methylphenyl)methyl]acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4,6-dimethyl-3-oxo-[1,2]thiazolo[5,4-b]pyridin-2-yl)-N-[(4-methylphenyl)methyl]acetamide
• 化学式: C₁₈H₁₉N₃O₂S
• 分子量: 341.4
• InChiKey: APJVKLYODVFORU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  87.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Methods and Compositions for Modulating Glycosylation
  申请人：Walker Kahne Suzanne

  公开号：US20090325944A1

  公开（公告）日：2009-12-31

  The invention relates to methods and products for modulating glycosylation of proteins. The invention is useful for treating glycosylation-associated disorders such as neurodegeneration, diabetes, including complications of diabetes such as insulin resistance, nephropathy, microvascular damage, and endothelial dysfunction. The invention also relates in part to assays that are useful for identifying and testing candidate compounds for modulating glycosylation of proteins.