申请人:Rauwald Urs
公开号:US20100247477A1
公开(公告)日:2010-09-30
This invention pertains generally to supramolecular polymers comprising a polymeric molecule linked to a first CB[8] guest molecule and an attachment compound linked to a second CB[8] guest molecule, wherein the first and second CB[8] guest molecules form a ternary host-guest complex with a CB[8] molecule which non-covalently links the polymeric molecule and the attachment compound in a supramolecular polymer. These polymers are useful as vehicles for delivery of a therapeutic compound for use in a method of treatment of the human or animal body, in particular for use in a method of delivering the therapeutic compound to a target site in an individual. The invention also provides methods for the preparation of the supramolecular polymers.
这项发明涉及一般的超分子聚合物,包括将聚合物分子与第一个CB[8]宾主分子连接,并将附着化合物与第二个CB[8]宾主分子连接,其中第一个和第二个CB[8]宾主分子与CB[8]分子形成三元宿主-客体复合物,CB[8]分子非共价地连接聚合物分子和附着化合物形成超分子聚合物。这些聚合物可用作传递治疗化合物的载体,用于治疗人体或动物体的方法,特别是用于将治疗化合物传递到个体的靶位点的方法。该发明还提供了制备超分子聚合物的方法。