Pyridinchlorsulfonat | 14206-10-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Pyridinchlorsulfonat
• 英文别名: pyridine;sulfurochloridic acid
• CAS: 14206-10-1
• 化学式: C5H6ClNO3S
• 分子量: 195.62
• InChiKey: UFWWAKOWSBGGCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.11
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  75.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为试剂：
  描述：

  甲基二氯磺酸酯 、 4-methoxybenzenesulfonic acid pyridinium salt 、 碳酸二甲酯 在 Pyridinchlorsulfonat 、 水 、 methylene bis(4-methoxybenzenesulfonate) 作用下， 反应 2.0h， 以so as to obtain a desired product, methylene bis(4-methoxybenzenesulfonate)的产率得到methylene bis(4-methoxybenzenesulfonate)
  参考文献：
  名称：

  Process for production of bis-quaternary ammonium salt, and novel intermediate

  摘要：

  目的：提供一种高效生产双季铵盐和其新的合成中间体的方法。 解决方案：本发明涉及一种生产双季铵盐的方法，其通式为[3]，包括将一种通式为[1]的二磺酸酯（在该式中，两个R1和T的定义如权利要求1所述）与一种通式为[2]的三级胺（在该式中，R3至R5的定义如权利要求1所述）和一种通式为[1']的二磺酸酯反应（在该式中，两个R16分别独立地表示卤素原子或C1-C3氟烷基，两个m分别独立地表示1至5的整数）。

  公开号：

  US08716513B2

文献信息

• METHOD FOR PRODUCING SUGAR HAVING SULFATE GROUP AND/OR PHOSPHATE GROUP
  申请人：GLYTECH, INC.

  公开号：US20200062794A1

  公开（公告）日：2020-02-27

  An object of the invention is to provide a method of uniformly and efficiently producing a saccharide having a sulfate group and/or a phosphate group in the molecule, or a compound containing the saccharide. [Solution] The present invention provides a method of producing a saccharide having a sulfate group and/or a phosphate group. The method comprises (a) a step of preparing a “first saccharide having a non-protected sulfate group and/or a non-protected phosphate group” and a “second saccharide having a non-protected sulfate group and/or a non-protected phosphate group” and (b) a step of condensing the first saccharide and the second saccharide prepared in the step (a) with each other.

  该发明的目的是提供一种均匀高效地生产具有硫酸基团和/或磷酸基团的糖苷或含有该糖苷的化合物的方法。【解决方案】本发明提供了一种生产具有硫酸基团和/或磷酸基团的糖苷的方法。该方法包括(a)制备“具有非保护硫酸基团和/或非保护磷酸基团的第一糖苷”和“具有非保护硫酸基团和/或非保护磷酸基团的第二糖苷”的步骤，以及(b)将步骤(a)中制备的第一糖苷和第二糖苷进行缩合的步骤。
• PROCESS FOR PRODUCTION OF BIS-QUATERNARY AMMONIUM SALT, AND NOVEL INTERMEDIATE
  申请人：Okamoto Kuniaki

  公开号：US20120130107A1

  公开（公告）日：2012-05-24

  Object To provide a method for producing a bis-quaternary ammonium salt efficiently and a novel synthetic intermediate thereof. Solution The present invention relates to a method for producing a bis-quaternary ammonium salt represented by a general formula [3] which comprises reacting a disulfonic acid ester represented by a general formula [1] (in the formula, definitions of two R 1 's and T are as described in claim 1 ) with a tertiary amine represented by a general formula [2] (in the formula, definitions of R 3 to R 5 are as described in claim 1 ), and a disulfonic acid ester represented by a general formula [1′] (in the formula, two R 16 's represent independently a halogen atom or a C1-C3 fluoroalkyl group, and two m's represent independently an integer of 1 to 5).

  提供一种高效生产双季铵盐和其新型合成中间体的方法。本发明涉及一种生产由通用式[3]表示的双季铵盐的方法，包括将由通用式[1]表示的二磺酸酯（在该式中，两个R1和T的定义如权利要求1中所述）与由通用式[2]表示的三级胺（在该式中，R3到R5的定义如权利要求1中所述）以及由通用式[1']表示的二磺酸酯（在该式中，两个R16独立表示卤原子或C1-C3氟烷基，两个m独立表示1至5的整数）反应。
• Process for the preparation of ursodeoxycholic acid disodium 3,7-disulfate
  申请人：PRODOTTI CHIMICI E ALIMENTARI SPA

  公开号：EP2221313A1

  公开（公告）日：2010-08-25

  Process for preparing the disodium salt of ursodeoxycholic acid 3,7-disulfate comprising the following steps: a) reaction of ursodeoxycholic acid with a complex of trimethylamine-sulphuric anhydride, to obtain the ursodeoxycholic acid 3,7-disulfate di-trimethylammonium reaction intermediate; b) treatment of the di-trimethylammonium salt of ursodeoxycholic acid 3,7-disulfate with organic or inorganic sodium bases to obtain the tri-sodium salt of ursodeoxycholic acid 3,7-disulfate; c) treatment with an inorganic acid in presence of isopropanol up to a pH comprised in the range between 3.0 and 4.5, to obtain the disodium salt of ursodeoxycholic acid 3,7-disulfate in solution; d) removal of the salts present and obtaining the disodium salt ofursodeoxycholic acid 3,7-disulfate.

  制备3,7-二硫酸盐熊去氧胆酸二钠的过程包括以下步骤：a）将熊去氧胆酸与三甲胺硫酸酐复合物反应，得到熊去氧胆酸3,7-二硫酸盐二三甲基铵反应中间体；b）用有机或无机钠碱处理熊去氧胆酸3,7-二硫酸盐二三甲基铵盐，得到熊去氧胆酸3,7-二硫酸盐三钠盐；c）在异丙醇存在下用无机酸处理至pH在3.0至4.5范围内，以得到熊去氧胆酸3,7-二硫酸盐二钠的溶液；d）去除存在的盐并获得熊去氧胆酸3,7-二硫酸盐二钠。
• A method for purification of influenza virus
  申请人：Juridical Foundation The Chemo-Sero-Therapeutic Research Institute

  公开号：EP0171086A2

  公开（公告）日：1986-02-12

  Disclosed is an improved method for the purification of an influenza virus, which comprises subjecting a solution containing the influenza virus to column chromatography using, as a gel for chromatography, a sulfuric acid ester of cellulose or a crosslinked polysaccharide. The method can provide highly purified influenza virus which is useful for obtaining an effective vaccine against influenza.

  本发明公开了一种用于纯化流感病毒的改进方法，包括使用纤维素的硫酸酯或交联多糖作为层析用凝胶，对含有流感病毒的溶液进行柱层析。该方法可提供高度纯化的流感病毒，有助于获得有效的流感疫苗。
• HYDROGENATED RING-OPENING METATHESIS COPOLYMER AND PROCESS FOR PRODUCING THE SAME
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1275676A1

  公开（公告）日：2003-01-15

  A hydrogenated ring-opening metathesis polymer which comprises at least a structural unit [B] of the following general formula [3] and/or a structural unit [C] of the following general formula [4]: (wherein R8 to R11 and R13 to R16 are independently a hydrogen atom or a linear, branched or cyclic alkyl group having 1 to 10 carbon atoms; and X2 and X3 are -O- or -CR122- (R12 represents a hydrogen atom or a linear or branched alkyl group having 1 to 10 carbon atoms) and may be the same or different each other; one of Y1 and Y2 is -(C=O)- and the other is -CR182- (R18 represents a hydrogen atom or a linear or branched alkyl group having 1 to 10 carbon atoms); and m and n are 0 or an integer of 1 to 3).

  一种氢化开环偏析聚合物，它至少包括以下通式[3]的结构单元[B]和/或以下通式[4]的结构单元[C]： (其中 R8 至 R11 和 R13 至 R16 独立地为氢原子或具有 1 至 10 个碳原子的直链、支链或环状烷基；X2 和 X3 为-O-或-CR122-（R12 代表氢原子或具有 1 至 10 个碳原子的直链或支链烷基）且可以相同或互不相同；Y1 和 Y2 中的一个是-(C=O)-，另一个是-CR182-（R18 代表氢原子或具有 1 至 10 个碳原子的直链或支链烷基）；以及 m 和 n 是 0 或 1 至 3 的整数。）