2-Isothiocyanatobenzenesulfonic acid | 131417-69-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Isothiocyanatobenzenesulfonic acid
• CAS: 131417-69-1
• 化学式: C₇H₅NO₃S₂
• 分子量: 215.3
• InChiKey: JNFXJMZXZLYTOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  107
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• A method for analysing a metabolic pathway
  申请人：Target Discovery, Inc.

  公开号：EP2293056A2

  公开（公告）日：2011-03-09

  A method for analyzing a metabolic pathway, comprising (a) administering to a subject a known ratio of a labeled substrate and an unlabeled substrate, wherein said labeled substrate labeled with a stable isotope and said unlabeled substrate having a natural abundance of said stable isotope; (b) allowing the labeled substrate and the unlabeled substrate to be at least partially metabolized to form a labeled target metabolite and an unlabeled target metabolite; (c) generating mass spectral data from a plurality of samples from said subject at a plurality of time points; and (d) determining a plurality of relative abundances of said labeled target metabolite to said unlabeled target metabolite from the mass spectral data of at least one of said samples and comparing said plurality of relative abundances to said known ratio of said labeled substrate and said unlabeled substrate.

  一种分析代谢途径的方法，包括 (a) 向受试者施用已知比例的标记底物和未标记底物，其中所述标记底物用稳定同位素标记，所述未标记底物具有所述稳定同位素的天然丰度；(b) 使标记底物和未标记底物至少部分代谢形成标记目标代谢物和未标记目标代谢物；(c) 从所述受试者在多个时间点的多个样本中生成质谱数据；以及 (d) 从至少一个所述样本的质谱数据中确定所述标记目标代谢物与所述未标记目标代谢物的多个相对丰度，并将所述多个相对丰度与所述标记底物和所述未标记底物的已知比率进行比较。
• Protein separation via multidimensional electrophoresis
  申请人：Target Discovery, Inc.

  公开号：US20030106797A1

  公开（公告）日：2003-06-12

  The present method provides methods and apparatus for separating proteins using a series of electrophoretic methods that utilize controlled fractionation and labeling techniques to resolve mixtures of proteins. The samples for each electrophoretic method other than the initial method, contain only a subset of proteins resolved in the preceding method. The methods can be used in a variety of different applications including, creating proteomic databases, comparative expression studies, diagnostics, structure activity relationships and metabolic engineering investigations.

  本方法提供了使用一系列电泳方法分离蛋白质的方法和装置，这些方法利用受控分馏和标记技术来分辨蛋白质混合物。除初始方法外，每种电泳方法的样品只包含前一种方法所分离的蛋白质的子集。这些方法可用于各种不同的应用，包括创建蛋白质组数据库、比较表达研究、诊断、结构活性关系和代谢工程研究。
• Labeling of protein samples
  申请人：Target Discovery, Inc.

  公开号：US20030119069A1

  公开（公告）日：2003-06-26

  Provided are methods of labeling multiple proteins in protein mixtures to prepare the samples for identification and analysis, and useful in developing a proteomics database.

  本文提供了对蛋白质混合物中的多种蛋白质进行标记的方法，以便为鉴定和分析样本做好准备，并有助于开发蛋白质组学数据库。
• Protein separation by electrophoresis
  申请人：Target Discovery, Inc.

  公开号：US20040262160A1

  公开（公告）日：2004-12-30

  The present method provides methods and apparatus for separating proteins using a series of electrophoretic methods that utilize controlled fractionation and labeling techniques to resolve mixtures of proteins. The samples for each electrophoretic method other than the initial method, contain only a subset of proteins resolved in the preceding method. The methods can be used in a variety of different applications including, creating proteomic databases, comparative expression studies, diagnostics, structure activity relationships and metabolic engineering investigations.

  本方法提供了使用一系列电泳方法分离蛋白质的方法和装置，这些方法利用受控分馏和标记技术来分辨蛋白质混合物。除初始方法外，每种电泳方法的样品只包含前一种方法所分离的蛋白质的子集。这些方法可用于各种不同的应用，包括创建蛋白质组数据库、比较表达研究、诊断、结构活性关系和代谢工程研究。
• NUCLEIC ACID PROBES AND PROTEIN PROBES
  申请人：BECKMAN INSTRUMENTS, INC.

  公开号：EP0487718A1

  公开（公告）日：1992-06-03