4-[(4-Fluorophenyl)methyl-(2-fluorophenyl)sulfonylamino]benzamide | 1571780-11-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[(4-Fluorophenyl)methyl-(2-fluorophenyl)sulfonylamino]benzamide
• 英文别名: 4-[(4-fluorophenyl)methyl-(2-fluorophenyl)sulfonylamino]benzamide
• CAS: 1571780-11-4
• 化学式: C₂₀H₁₆F₂N₂O₃S
• 分子量: 402.421
• InChiKey: RJGXILPGUGXXBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  88.8
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-氟苯磺酰氯 在 potassium carbonate 、 三乙胺 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 36.0h， 生成 4-[(4-Fluorophenyl)methyl-(2-fluorophenyl)sulfonylamino]benzamide
  参考文献：
  名称：

  Lactam sulfonamides as potent inhibitors of the Kv1.5 potassium ion channel

  摘要：

  A series of lactam sulfonamides has been discovered and optimized as inhibitors of the Kv1.5 potassium ion channel for treatment of atrial fibrillation. In vitro structure-activity relationships from lead structure C to optimized structure 3y are described. Compound 3y was evaluated in a rabbit PD-model and was found to selectively prolong the atrial effective refractory period at submicromolar concentrations. (c) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.01.067

文献信息

• Lactam sulfonamides as potent inhibitors of the Kv1.5 potassium ion channel
  作者：Roine I. Olsson、Ingemar Jacobson、Tommy Iliefski、Jonas Boström、Öjvind Davidsson、Ola Fjellström、Annika Björe、Christina Olsson、Johan Sundell、Ulrik Gran、Jonna Gyll、Jesper Malmberg、Olle Hidestål、Hans Emtenäs、Tor Svensson、Zhong-Qing Yuan、Gert Strandlund、Annika Åstrand、Emma Lindhardt、Gunilla Linhardt、Elin Forsström、Ågot Högberg、Frida Persson、Birgit Andersson、Anna Rönnborg、Boel Löfberg

  DOI：10.1016/j.bmcl.2014.01.067

  日期：2014.3

  A series of lactam sulfonamides has been discovered and optimized as inhibitors of the Kv1.5 potassium ion channel for treatment of atrial fibrillation. In vitro structure-activity relationships from lead structure C to optimized structure 3y are described. Compound 3y was evaluated in a rabbit PD-model and was found to selectively prolong the atrial effective refractory period at submicromolar concentrations. (c) 2014 Elsevier Ltd. All rights reserved.