4-(5-p-tolylamino-[1,3,4]thiadiazol-2-ylsulfanyl)-benzenesulfonylchloride | 1076689-63-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-(5-p-tolylamino-[1,3,4]thiadiazol-2-ylsulfanyl)-benzenesulfonylchloride
• 英文别名: 4-[[5-(4-Methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]benzenesulfonyl chloride；4-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]benzenesulfonyl chloride
• CAS: 1076689-63-8
• 化学式: C₁₅H₁₂ClN₃O₂S₃
• 分子量: 397.93
• InChiKey: FPSPMMRJLZVAKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  134
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  对氯甲苯 、 4-(5-amino-1,3,4-thiadiazol-2-ylsulfanyl)benzenesulfonyl chloride 以 乙醚 为溶剂， 反应 0.5h， 以68%的产率得到4-(5-p-tolylamino-[1,3,4]thiadiazol-2-ylsulfanyl)-benzenesulfonylchloride
  参考文献：
  名称：

  Synthesis and biological evaluation of 2-amino-5-sulfanyl-1,3,4-thiadiazole derivatives as antidepressant, anxiolytics and anticonvulsant agents

  摘要：

  A new series of 2-amino-5-sulfanyl-1,3,4-thiadiazole derivatives has been synthesized. The newly synthesized compounds were characterized by analytical and spectral methods. Compounds were screened for central nervous system activity. Compounds 1, 5, 7, 10, 14 exhibited significant antidepressant, anxiolytic and anticonvulsant activity in comparison to the reference drugs.

  DOI：

  10.1007/s00044-010-9308-3

文献信息

• Synthesis and biological evaluation of 2-amino-5-sulfanyl-1,3,4-thiadiazole derivatives as antidepressant, anxiolytics and anticonvulsant agents
  作者：Rajesh Sharma、Ganesh Prasad Misra、Jitendra Sainy、Subhash Chandra Chaturvedi

  DOI：10.1007/s00044-010-9308-3

  日期：2011.3

  A new series of 2-amino-5-sulfanyl-1,3,4-thiadiazole derivatives has been synthesized. The newly synthesized compounds were characterized by analytical and spectral methods. Compounds were screened for central nervous system activity. Compounds 1, 5, 7, 10, 14 exhibited significant antidepressant, anxiolytic and anticonvulsant activity in comparison to the reference drugs.