(3S)-3-amino-3-(4-methylsulfonylphenyl)propan-1-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3S)-3-amino-3-(4-methylsulfonylphenyl)propan-1-ol
• 化学式: C₁₀H₁₅NO₃S
• 分子量: 229.3
• InChiKey: MFRMLJPOVFGFHD-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  88.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• MODULATORS OF ROR-GAMMA
  申请人：Vitae Pharmaceuticals, LLC

  公开号：US20210094940A1

  公开（公告）日：2021-04-01

  Provided are novel compounds of Formula I pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by RORγ. Also provided are pharmaceutical compositions comprising the novel compounds of Formula I and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders.