5-(4-(4-Chloro-phenoxy)-phenyl)-pyrimidine,2,4,-6-trione | 333997-32-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(4-(4-Chloro-phenoxy)-phenyl)-pyrimidine,2,4,-6-trione
• 英文别名: 5-[4-(4-Chlorophenoxy)phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione；5-[4-(4-chlorophenoxy)phenyl]-1,3-diazinane-2,4,6-trione
• CAS: 333997-32-3
• 化学式: C₁₆H₁₁ClN₂O₄
• 分子量: 330.727
• InChiKey: YRQZTUJUCCUNRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  84.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Barbituric acid derivatives
  申请人：——

  公开号：US20020187991A1

  公开（公告）日：2002-12-12

  Derivatives of 5,5-disubstituted pyrimidine-2,4,6-trianones are disclosed. These compounds have antitumor and antimetastatic activity.

  5,5-二取代嘧啶-2,4,6-三酮的衍生物已被披露。这些化合物具有抗肿瘤和抗转移活性。
• NEW PYRIMIDINE-2,4,6-TRIONE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1226128B1

  公开（公告）日：2005-02-23
• US6498252B1
  申请人：——

  公开号：US6498252B1

  公开（公告）日：2002-12-24
• US6716845B2
  申请人：——

  公开号：US6716845B2

  公开（公告）日：2004-04-06
• [EN] NEW PYRIMIDINE-2,4,6-TRIONE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS<br/>[FR] NOUVEAUX DERIVES DE PYRIMIDINE-2,4,6-TRIONE, LEURS PROCEDES DE PRODUCTION ET LES AGENTS PHARMACEUTIQUES CONTENANT CES COMPOSES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2001025217A1

  公开（公告）日：2001-04-12

  Compounds of formula (I) in which R1 represents a substituted or unsubstituted phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl, phenylamino or phenylmethyl residue, and R2 represents an optionally substituted aryl or heteroaryl residue, with metallo-proteinase inhibitor activity.