4-[2-[4-[2-[4-[bis(oxiran-2-ylmethyl)amino]-3,5-dimethylphenyl]propan-2-yl]phenyl]propan-2-yl]-2,6-dimethyl-N,N-bis(oxiran-2-ylmethyl)aniline | 103490-08-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[2-[4-[2-[4-[bis(oxiran-2-ylmethyl)amino]-3,5-dimethylphenyl]propan-2-yl]phenyl]propan-2-yl]-2,6-dimethyl-N,N-bis(oxiran-2-ylmethyl)aniline
• CAS: 103490-08-0
• 化学式: C₄₀H₅₂N₂O₄
• 分子量: 624.9
• InChiKey: KGSLDHZAZZJGDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  46
• 可旋转键数：
  14
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  56.6
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Process for the preparation of 11-oxaprostaglandins and intermediates therein
  申请人：——

  公开号：US20030166948A1

  公开（公告）日：2003-09-04

  For the preparation of an 11-oxaprostaglandin such as [2R,(1E,3R),3S,(4Z),4R)]-7-{tetrahydro-2-[4-(3-chlorophenoxy)-3-hydroxy-1-butenyl]-4-hydroxy-3-furanyl}-4-heptenoic acid and its ester derivatives, a novel process uses a novel enantiomerically enriched compound for formula (1) wherein the bond between carbon atoms y and z is either a single or double bond; R 1 is selected from vinyl, trialkylsilylethynyl, a formyl group protected as an acetal, or a protected hydroxymethyl group; R 2 is C 1-5 alkyl, optionally substituted at the terminus with an aryloxy or alkoxy group; and R 3 -R 6 are independently selected from C 1-6 alkyl and C 6-10 aryl. 1

  用于制备11-氧代前列腺素的新型方法，例如[2R，（1E，3R），3S，（4Z），4R）]-7-{四氢-2-[4-（3-氯苯氧）-3-羟基-1-丁烯基]-4-羟基-3-呋喃基}-4-庚烯酸及其酯衍生物，采用新型对映富集化合物的公式（1），其中碳原子y和z之间的键为单键或双键；R1选择自乙烯基，三烷基硅基乙炔基，作为缩醛保护的甲醛基，或保护的羟甲基基团；R2是C1-5烷基，可在末端用芳氧基或烷氧基取代；R3-R6分别选择自C1-6烷基和C6-10芳基。
• [EN] PROCESS FOR THE PREPARATION OF 11-OXAPROSTAGLANDINS AND INTERMEDIATES THEREIN<br/>[FR] PROCEDE DE PREPARATION DE 11-OXAPROSTAGLANDINES ET INTERMEDES
  申请人：CHIROTECH TECHNOLOGY LTD

  公开号：WO2001087897A1

  公开（公告）日：2001-11-22

  For the preparation of an 11-oxaprostaglandin such as [2R,(1E,3R),3S,(4Z),4R)]-7-tetrahydro-2-[4-(3-chlorophenoxy)-3-hydroxy-1-butenyl]-4-hydroxy-3-furanyl}-4-heptenoic acid and its ester derivatives, a novel process uses a novel enantiomerically enriched compound for formula (1) wherein the bond between carbon atoms y and z is either a single or double bond; R1 is selected from vinyl, trialkylsilylethynyl, a formyl group protected as an acetal, or a protected hydroxymethyl group; R2 is C¿1-5? alkyl, optionally substituted at the terminus with an aryloxy or alkoxy group; and R?3-R6¿ are independently selected from C¿1-6? alkyl and C6-10 aryl.

  为了制备类似于[2R，（1E，3R），3S，（4Z），4R）]-7-四氢-2-[4-（3-氯苯氧基）-3-羟基-1-丁烯基]-4-羟基-3-呋喃基}-4-庚烯酸及其酯衍生物的11-氧代前列腺素，采用了一种新型手段，使用了手性富集的化合物（1），其中碳原子y和z之间的键为单键或双键；R1从乙烯基，三烷基硅基乙炔基，以醚保护的甲酰基或保护的羟甲基基团中选择；R2是C1-5烷基，其末端可选地被芳氧基或烷氧基取代；R3-R6分别独立地选择自C1-6烷基和C6-10芳基。
• Photoimageable permanent resist
  申请人：AMP-AKZO CORPORATION (a Delaware corp.)

  公开号：EP0359216A1

  公开（公告）日：1990-03-21

  Compositions which include an acidified epoxy oligomer, a free radical photoinitiator and a monomer capable of being polymerized by the photoinitiator are used to form aqueous developable, photodefined coatings useful as permanent solder masks for printed circuits and permanent plating resists for additive printed wiring boards. The process for using the compositions include application as a fluid in solvents; drying; exposing to ultraviolet light; developing in an aqueous alkaline solution; and crosslinking the acidified, epoxy oligomers. The articles produced include printed wiring boards with the permanent, photoimaged resist composition thereon.

  包括酸化环氧低聚物、自由基光引发剂和能被光引发剂聚合的单体的组合物用于形成可显影的水性光定义涂层，可用作印刷电路的永久阻焊层和添加剂印刷线路板的永久阻镀层。 组合物的使用过程包括：在溶剂中作为流体使用；干燥；暴露于紫外线下；在碱性水溶液中显影；以及交联酸化的环氧低聚物。生产出的产品包括带有永久性光成像抗蚀剂组合物的印刷线路板。
• Process of making 2,5-diaryl tetrahydrofurans and analogs thereof useful as paf antagonists
  申请人：MERCK & CO. INC.

  公开号：EP0465122A1

  公开（公告）日：1992-01-08

  The present invention is directed to a process of making tetrahydrofuran of the formula (2D) resulting in 2,5-diaryltetrahydrofuran PAF antagonists of pharmaceutically acceptable purity.

  本发明涉及一种制造式 (2D) 四氢呋喃的工艺 从而得到药学上可接受纯度的 2,5-二叔基四氢呋喃 PAF 拮抗剂。
• Damage tolerant composites containing infusible particles
  申请人：HERCULES INCORPORATED

  公开号：EP0486044A2

  公开（公告）日：1992-05-20

  Damage tolerant structural composites comprising high strength filaments in the form of bundles or tows of continuous fiber and a crosslinked epoxy resin matrix are disclosed. The invention, more particularly relates to improvements in the crosslinked epoxy resin matrix which provide the structural composites with high post impact compressive strength while maintaining such other desirable attributes of epoxy composites as good high temperature performance, solvent resistance and good processing characteristics. The crosslinked epoxy resin matrix contains infusible particles that reside primarily between plies of the composite and have a median particle size between 5 - 75 microns. Prepregs for making the damage tolerant composites and methods of making such prepregs and the epoxy resin compositions thereof are also disclosed. The epoxy resin compositions contain the infusible particles which become segregated as to size on a surface layer of the prepreg during the process of combining the high strength filaments of the prepreg and the resin containing the epoxy resin composition. Alternatively, the infusible particles may be disposed directly on the epoxy resin surface of the prepreg.

  本发明公开了由连续纤维束或纤维束形式的高强度长丝和交联环氧树脂基体组成的耐损伤结构复合材料。本发明尤其涉及对交联环氧树脂基体的改进，使结构复合材料具有较高的冲击后抗压强度，同时保持环氧树脂复合材料的其他理想特性，如良好的高温性能、耐溶剂性和良好的加工特性。交联环氧树脂基体含有可注入颗粒，这些颗粒主要位于复合材料的层间，中值粒径在 5 - 75 微米之间。此外，还公开了用于制造耐损伤复合材料的预浸料、制造此类预浸料的方法及其环氧树脂组合物。环氧树脂组合物中含有可注入颗粒，在将预浸料中的高强度长丝与含有环氧树脂组合物的树脂结合的过程中，这些可注入颗粒会在预浸料的表层上按尺寸分离。或者，可注入颗粒可以直接放置在预浸料的环氧树脂表面。