O-(thiophen-2-ylmethyl)hydroxylamine;hydrochloride | 39684-29-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: O-(thiophen-2-ylmethyl)hydroxylamine;hydrochloride
• CAS: 39684-29-2
• 化学式: C5H8ClNOS
• 分子量: 165.64
• InChiKey: HHQRMKABZGABRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.56
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  63.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• New indenoindolone compounds
  申请人：——

  公开号：US20030125369A1

  公开（公告）日：2003-07-03

  Compound of formula (I): 1 wherein R represents hydrogen, optionally substituted alkyl or alkenyl, R 1 to R 8 , which may be identical or different, each represents hydrogen, optionally substituted alkyl, hydroxy, acyloxy, optionally substituted amino, carboxy, optionally substituted alkoxy, or alkenyloxy, or one of R 1 to R 8 forms, with another of R 1 to R 8 that is adjacent, an alkylenedioxy group, X represents oxygen or NR 16 wherein R 16 represents hydrogen, alkyl, aryl or arylalkyl, R 9 represents hydrogen, aryl, heteroaryl, or optionally substituted, saturated or unsaturated alkyl, isomers thereof, and addition salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as anti-cancer agents.

  化合物的分子式（I）如下： 其中R代表氢，可选择地取代的烷基或烯基，R1至R8，可以相同也可以不同，每个代表氢，可选择地取代的烷基，羟基，酰氧基，可选择地取代的氨基，羧基，可选择地取代的烷氧基，或烯基氧基，或者R1至R8中的一个与相邻的另一个R1至R8形成烷二氧基基团，X代表氧或NR16，其中R16代表氢，烷基，芳基或芳基烷基，R9代表氢，芳基，杂芳基，或可选择地取代的饱和或不饱和烷基，其异构体，以及其与药用酸或碱的可接受盐。含有该化合物的药物制剂可用作抗癌剂。
• [EN] 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS<br/>[FR] COMPOSES DE 4-AMINOPYRIDO[2,3-D]PYRIMIDINE A DISUBSTITUTION 5,7
  申请人：ABBOTT LAB

  公开号：WO2000023444A1

  公开（公告）日：2000-04-27

  A method of inhibiting adenosine kinase by administering one of more compounds of formula (I), wherein R?1, R2, R3 and R4¿ are defined, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above in combination with a pharmaceutically acceptable carrier, and a method of treating cerebral ischemia, epilepsy, nociperception, inflammation and sepsis in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound thereof, a process for preparing said compounds, and compounds having the above formula wherein R?1, R2, R3 and R4¿ are separately defined.

  一种通过给予式(I)中的一个或多个化合物来抑制腺苷激酶的方法，其中R1、R2、R3和R4被定义，以及包含上述化合物的治疗有效量与药学可接受载体组合的制药组合物，以及一种治疗哺乳动物的脑缺血、癫痫、疼痛感知、炎症和败血症的方法，包括给予哺乳动物上述化合物的治疗有效量，制备上述化合物的方法以及具有上述式中R1、R2、R3和R4分别被定义的化合物。
• Macrolide compounds
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0307225A2

  公开（公告）日：1989-03-15

  Compounds of formula (I) and salts thereof, wherein R¹ represents a methyl, ethyl or isopropyl group; R² represents a C₂₋₇ alkyl group interrupted by an oxygen or sulphur atom or an aryl, aryl C₁₋₇ alkyl or heteroaryl C₁₋₇ alkyl group; OR³ is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms; and the group =NOR² is in the E configuration. These compounds may be used for controlling insect, acarine, nematode or other pests.

  式(I)化合物 及其盐类，其中 R¹ 代表甲基、乙基或异丙基；R² 代表被氧原子或硫原子间断的 C₂₋₇ 烷基或芳基、芳 C₁₋₇ 烷基或杂芳基 C₁₋₇ 烷基；OR³ 是羟基或具有多达 25 个碳原子的取代羟基；基团 =NOR² 为 E 型。 这些化合物可用于防治昆虫、螨虫、线虫或其他害虫。
• Octahydronaphthalene oxime derivatives for cholesterol biosynthesis inhibition, their preparation and use
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0570245A2

  公开（公告）日：1993-11-18

  Compounds of formula (I) : (in which: R is hydrogen, methyl or hydroxy; X is alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or a heterocyclic group; A is a single bond, or an alkylene, alkenylene, alkynylene or alkadienylene group; Y is hydrogen, aryl, cycloalkyl or a heterocyclic group) have the ability to inhibit the biosynthesis of cholesterol, and can thus be used for the treatment and prophylaxis of diseases relating to high blood cholesterol levels.

  式(I)化合物： 其中R为氢、甲基或羟基；X为烷基、烯基、环烷基、芳基、芳烷基或杂环基；A为单键或亚烷基、亚烯基、亚炔基或烷二烯基；Y为氢、芳基、环烷基或杂环基）具有抑制胆固醇生物合成的能力，因此可用于治疗和预防与高血胆固醇水平有关的疾病。
• US5192777A
  申请人：——

  公开号：US5192777A

  公开（公告）日：1993-03-09