(2-Azido-1-chloroethyl)benzene | 18756-02-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-Azido-1-chloroethyl)benzene
• CAS: 18756-02-0
• 化学式: C8H8ClN3
• 分子量: 181.62
• InChiKey: NUQPWXPHGAXOER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  14.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] METHOD OF CONVERTING ALCOHOL TO HALIDE<br/>[FR] PROCÉDÉ DE CONVERSION D'UN ALCOOL EN HALOGÉNURE
  申请人：UNIV SAARLAND

  公开号：WO2016202894A1

  公开（公告）日：2016-12-22

  The present invention relates to a method of converting an alcohol into a corresponding halide. This method comprises reacting the alcohol with an optionally substituted aromatic carboxylic acid halide in presence of an N-substituted formamide to replace a hydroxyl group of the alcohol by a halogen atom. The present invention also relates to a method of converting an alcohol into a corresponding substitution product. The second method comprises: (a) performing the method of the invention of converting an alcohol into the corresponding halide; and (b) reacting the corresponding halide with a nucleophile to convert the halide into the nucleophilic substitution product.

  本发明涉及一种将醇转化为相应卤化物的方法。该方法包括在N-取代甲酰胺的存在下，将醇与可选择取代的芳香羧酸卤化物反应，以通过卤原子取代醇的羟基。本发明还涉及一种将醇转化为相应取代产物的方法。第二种方法包括：(a)执行将醇转化为相应卤化物的本发明方法；以及(b)将相应卤化物与亲核试剂反应，将卤化物转化为亲核取代产物。
• METHOD FOR PREPARING ENAMIDE COMPOUND AND RUTHENIUM COMPLEX CATALYST USED THEREIN
  申请人：POSTECH ACADEMY-INDUSTRY FOUNDATION

  公开号：US20170291885A1

  公开（公告）日：2017-10-12

  Provided is a method for preparing an enamide compound, which includes reacting an organic azide compound having α-hydrogen and an anhydride by addition of a ruthenium complex catalyst in the presence of an ionic liquid, and a ruthenium complex catalyst used herein.

  提供了一种制备烯酰胺化合物的方法，包括在存在离子液体的情况下，通过向具有α-氢的有机叠氮化合物和酸酐添加钌配合物催化剂来反应，并且这里使用的是一种钌配合物催化剂。
• Azidochlorination and diazidization of glycals
  申请人：BIOMIRA, INC.

  公开号：EP0340780A2

  公开（公告）日：1989-11-08

  The invention describes a one-pot single step procedure for the azidochlorination or diazidization of glycals, including glycal elements of carbohydrates. Compounds such as 3,4,6-tri-O-benzyl-2-azido-2-deoxy-­alpha-D-galactopyranosyl chloride, and 3,4,6-tri-O-­benzyl-2-azido-2-deoxy-alpha-,beta-D-galactopyranose are prepared from tri-O-benzyl galactal as well as 3,4,6-tri-O-acetyl-2-azido-2-deoxy-D-alpha-­galactopyranosyl chloride and 3,6,-di-O-acetyl-4-O-­[2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl]-2-­azido-2-deoxy-alpha-D-glycopyranosyl chloride from their respective O-acetylated glycal derivatives by the addition of azido chloride which is chemically generated in situ. A method using 3,4,6-tri-O-acetyl-­2-azido-2-deoxy-alpha-D-galacto-pyranosyl chloride for the synthesis of antigenic determinants such as the terminal asialo GM₁(beta-D-Gal (1->3)-beta-D-GalNAc-OR) has been demonstrated. The conversion of the subject synthon into 3,4,6-tri-O-acetyl-2-azido-2-deoxy-alpha-­D-galactopyranosyl bromide and 1,3,4,6-tetra-O-acetyl-­2-azido-2-deoxy-alpha-D-galactopyranose is also described. A further method for the synthetic generation of the Tn antigen (alpha-D-GalNAc-O-L-­serine) is also described.

  本发明描述了一种将糖醛（包括碳水化合物中的糖醛元素）进行叠氮氯化或重氮化的一步法程序。由三-O-苄基半乳糖以及 3,4,6-三-O-乙酰基-2-叠氮-2-脱氧-D-alpha-D-吡喃半乳糖酰氯和 3,4,6-三-O-苄基-2-叠氮-2-脱氧-alpha-,beta-D-吡喃半乳糖制备出 3,4,6-三-O-苄基-2-叠氮-2-脱氧-D-alpha-D-吡喃半乳糖等化合物、一种使用 3,4,6-二-O-乙酰基-4-O-[2,3,4,6-四-O-乙酰基-beta-D-吡喃半乳糖基]-2-叠氮-2-脱氧-D-alpha-D-吡喃糖基氯化物的方法，通过添加原位化学生成的叠氮氯化物，从各自的 O-乙酰化甘醛衍生物中制备出这些物质。一种使用 3,4,6-三-O-乙酰基-2-叠氮-2-脱氧-α-D-吡喃半乳糖酰氯合成抗原决定簇（如末端异构体 GM₁（beta-D-Gal (1->3)-beta-D-GalNAc-OR））的方法已经得到证实。此外，还介绍了将上述合成物转化为 3,4,6-O-三乙酰基-2-叠氮-2-脱氧-alpha-D-吡喃半乳糖溴化物和 1,3,4,6-O-四乙酰基-2-叠氮-2-脱氧-alpha-D-吡喃半乳糖的方法。还描述了合成 Tn 抗原（α-D-半乳糖醛酸-O-L-丝氨酸）的另一种方法。
• US4935503A
  申请人：——

  公开号：US4935503A

  公开（公告）日：1990-06-19