N,2-di-tert-butylaniline | 19298-56-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,2-di-tert-butylaniline
• 英文别名: N,2-Di-t-butylanilin；N-t-butyl-2-t-butylaniline；N,2-ditert-butylaniline
• CAS: 19298-56-7
• 化学式: C₁₄H₂₃N
• 分子量: 205.343
• InChiKey: NHBVNMOVWPANFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,2-di-tert-butylaniline 在 盐酸 、 sodium nitrite 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 以50%的产率得到N,2-di-tert-butyl-4-nitrosoaniline
  参考文献：
  名称：

  Hoefnagel, M. A.; Wepster, B. M., Recueil des Travaux Chimiques des Pays-Bas, 1989, vol. 108, # 3, p. 97 - 98

  摘要：

  DOI：

文献信息

• Isoprenyl Compounds and Methods Thereof
  申请人：Stock Jeffry B.

  公开号：US20100184768A1

  公开（公告）日：2010-07-22

  Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

  除其他事项外，本发明提供了新型异戊二烯基化合物，能够有效调节炎症反应，并提供包含这些异戊二烯基化合物的药物、化妆品、化妆品和局部组合物。本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或症状。本发明的促炎化合物可用于治疗或预防与抑制炎症反应相关的疾病或症状。因此，本发明还提供了用于治疗或预防与炎症相关的疾病或症状以及用于治疗或预防与抑制炎症反应相关的疾病或症状的方法。
• ISOPRENYL COMPOUNDS AND METHODS THEREOF
  申请人：Stock Jeffry B.

  公开号：US20130310559A1

  公开（公告）日：2013-11-21

  Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

  本发明提供了新型异戊烯基化合物，能够有效调节炎症反应，并且包括这些异戊烯基化合物的制药、化妆品、护肤品和局部组合物。本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。本发明的促炎化合物可用于治疗或预防与抑制炎症反应相关的疾病或病症。因此，本发明还提供了用于治疗或预防与炎症相关的疾病或病症以及用于治疗或预防与抑制炎症反应相关的疾病或病症的方法。
• Ziegler type catalyst composition
  申请人：EXXON RESEARCH AND ENGINEERING COMPANY

  公开号：EP0016581A1

  公开（公告）日：1980-10-01

  A catalyst system for alphaolefin type polymerizations, includes at least one hindered alkyl metal amide compound having the formula R'2YNR2 in combination with a Group IVA-VIII transition metal compound on a support and at least one Lewis base wherein R is C3 to C20 bulky alkyl, cycloalkyl, aralkyl, aryl or substituted aryl groups or R2N is a hindered cyclic amide group; R' is C, to C20 primary alkyl, secondary alkyl, tertiary alkyl, neopentyl alkyl, branched alkyl, cycloalkyl or aralkyl groups, and Y is aluminium, gallium or indium. The catalyst system provides polymers having increased isotactic stereoregularity as well as lower catalyst residue.

  一种用于α-烯烃类聚合反应的催化剂体系，包括至少一种具有式 R'2YNR2 的受阻烷基金属酰胺化合物，该化合物与一种位于载体上的 IVA-VIII 族过渡金属化合物和至少一种路易斯碱结合，其中 R 是 C3 至 C20 粗大烷基、环烷基、芳基、芳基或取代芳基，或 R2N 是受阻环酰胺基团；R' 是 C 至 C20 级烷基、仲烷基、叔烷基、新戊基、支链烷基、环烷基或芳烷基，Y 是铝、镓或铟。该催化剂体系提供的聚合物具有更高的异构立体规整度和更低的催化剂残留量。
• Isoprenyl compounds and methods thereof
  申请人：Signum Biosciences, Inc.

  公开号：US10314802B2

  公开（公告）日：2019-06-11

  Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

  除其他外，本发明提供了能够有效调节炎症反应的新型异戊烯基化合物，以及包含这些异戊烯基化合物的药物、化妆品、药妆和外用组合物。本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。本发明的促炎化合物可用于治疗或预防与抑制炎症反应有关的疾病或病症。因此，本发明还提供了治疗或预防与炎症有关的疾病或病症的方法，以及治疗或预防与抑制炎症反应有关的疾病或病症的方法。
• VAR2CSA-drug conjugates
  申请人：ZYMEWORKS INC.

  公开号：US10675355B2

  公开（公告）日：2020-06-09

  VAR2CSA-drug conjugates having biological activity are disclosed. Methods associated with preparation and use of such conjugates, as well as pharmaceutical compositions comprising such conjugates, are also disclosed.

  本研究公开了具有生物活性的 VAR2CSA-药物共轭物。还公开了与制备和使用此类共轭物相关的方法，以及包含此类共轭物的药物组合物。