5-Chloro-3-{[3-(trifluoromethyl)phenyl]methyl}-1,2,4-thiadiazole | 1221346-00-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-Chloro-3-{[3-(trifluoromethyl)phenyl]methyl}-1,2,4-thiadiazole
• 英文别名: 5-chloro-3-[[3-(trifluoromethyl)phenyl]methyl]-1,2,4-thiadiazole
• CAS: 1221346-00-4
• 化学式: C₁₀H₆ClF₃N₂S
• 分子量: 278.68
• InChiKey: LMFHFVLWQCAYBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] 2,7-DIAZASPIRO[3.5]NONANE COMPOUNDS<br/>[FR] COMPOSÉS DE 2,7-DIAZASPIRO[3.5]NONANE
  申请人：REMYND NV

  公开号：WO2015140132A1

  公开（公告）日：2015-09-24

  The present invention relates to a compound of formula (I) or a stereoisomer, enantiomer, racemic, or tautomer thereof, Formula (I), wherein R1, R3, R4, L1, L2, L3, L4, and n, have the same meaning as that defined in the claims and the description. The present invention also relates to compositions, in particular pharmaceuticals, comprising such compounds, and to uses of such compounds and compositions for the prevention and/or treatment of metabolic disorders and/or neurodegenerative diseases, and/or protein misfolding disorders.

  本发明涉及式（I）或其立体异构体、对映异构体、外消旋体或互变异构体的化合物，式（I）中，R1、R3、R4、L1、L2、L3、L4和n的含义与权利要求书和说明书中定义的含义相同。本发明还涉及包含这些化合物的组合物，特别是制药组合物，以及这些化合物和组合物用于预防和/或治疗代谢性疾病和/或神经退行性疾病和/或蛋白质错折性疾病的用途。
• Thiadiazole compound and use thereof
  申请人：Ihara Hideki

  公开号：US20060014962A1

  公开（公告）日：2006-01-19

  The thiadiazole compound represented by the formula (A): wherein R 1 represents a C1-C7 alkyl group, a C3-C7 alkenyl group, a C3-C7 alkynyl group and the like; R2 represents a C1-C4 alkyl group substituted with a hetero ring group in which the hetero ring group may be substituted, which the hetero ring group is a five-membered ring containing only an oxygen atom(s) or a sulfur atom(s) as a hetero atom(s); has an excellent arthropod pests controlling activity.

  公式(A)代表的噻二唑化合物，其中R1代表C1-C7烷基，C3-C7烯基，C3-C7炔基等；R2代表被杂环基取代的C1-C4烷基，其中杂环基可以被取代，该杂环基是一个仅包含氧原子或硫原子作为杂原子的五元环；具有优良的节肢动物害虫控制活性。
• THIADIAZOLE COMPOUND AND USE THEREOF
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1550661A1

  公开（公告）日：2005-07-06

  The thiadiazole compound represented by the formula (A) : wherein R1 represents a C1-C7 alkyl group, a C3-C7 alkenyl group, a C3-C7 alkynyl group and the like; R2 represents a C1-C4 alkyl group substituted with a hetero ring group in which the hetero ring group may be substituted, which the hetero ring group is a five-membered ring containing only an oxygen atom (s) or a sulfur atom(s) as a hetero atom(s); has an excellent arthropod pests controlling activity.

  式（A）代表的噻二唑化合物： 其中 R1 代表 C1-C7 烷基、C3-C7 烯基、C3-C7 炔基或类似基团；R2 代表被杂环基团取代的 C1-C4 烷基，其中杂环基团可被取代，杂环基团是仅含有一个氧原子或一个硫原子作为杂原子的五元环； 具有极佳的控制节肢动物害虫的活性。
• 2,7-DIAZASPIRO[3.5]NONANE COMPOUNDS
  申请人：reMYND NV

  公开号：EP3119782A1

  公开（公告）日：2017-01-25