2-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole | 887576-05-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
• CAS: 887576-05-8
• 化学式: C₁₈H₁₄Cl₄N₂O
• 分子量: 416.1
• InChiKey: VHVBYHWOJSMAKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  37.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• NOVEL K99-5278 SUBSTANCES AND PROCESS FOR PRODUCING THE SAM E
  申请人：THE KITASATO INSTITUTE

  公开号：EP1550726A1

  公开（公告）日：2005-07-06

  The present invention relates to effective drugs for mycosis caused by so called fungi such as fungi and yeast. The present invention is comprised of culturing a microorganism belonging to genus Streptomyces and having ability to produce K99-5278A substance, K99-5278B substance and K99-5278C substance in a medium, accumulating K99-5278A substance, K99-5278B substance and K99-5278C substance in the cultured medium and isolating K99-5278A substance, K99-5278B substance and K99-5278C substance from the cultured mass. The thus obtained substances can be expected as a novel antifungal agent.

  本发明涉及治疗由所谓真菌（如真菌和酵母菌）引起的真菌病的有效药物。本发明包括在培养基中培养一种属于链霉菌属并能产生 K99-5278A 物质、K99-5278B 物质和 K99-5278C 物质的微生物，在培养基中积累 K99-5278A 物质、K99-5278B 物质和 K99-5278C 物质，并从培养物中分离 K99-5278A 物质、K99-5278B 物质和 K99-5278C 物质。由此获得的物质有望成为一种新型抗真菌剂。
• Novel k99-5278 substance and a process for producing the same
  申请人：Omura Satoshi

  公开号：US20060014825A1

  公开（公告）日：2006-01-19

  The present invention relates to effective drugs for mycosis caused by so called fungi such as fungi and yeast. The present invention is comprised of culturing a microorganism belonging to genus Streptomyces and having ability to produce K99-5278A substance, K99-5278B substance and K99-5278C substance in a medium, accumulating K99-5278A substance, K99-5278B substance and K99-5278C substance in the cultured medium and isolating K99-5278A substance, K99-5278B substance and K99-5278C substance from the cultured mass. The thus obtained substances can be expected as a novel antifungal agent.

  本发明涉及治疗由所谓真菌（如真菌和酵母菌）引起的霉菌病的有效药物。本发明包括培养一种属于 链霉菌属 并能在培养基中产生 K99-5278A 物质、K99-5278B 物质和 K99-5278C 物质，在培养基中积累 K99-5278A 物质、K99-5278B 物质和 K99-5278C 物质，并从培养物中分离 K99-5278A 物质、K99-5278B 物质和 K99-5278C 物质。由此获得的物质有望成为一种新型抗真菌剂。
• BINDER COATED DISCONTINUOUS FIBERS WITH ADHERED PARTICULATE MATERIALS
  申请人：WEYERHAEUSER COMPANY

  公开号：EP0575516A1

  公开（公告）日：1993-12-29
• (CARBOXYL)ALKYLOXYALKYL DERIVATIVES OF CYCLODEXTRINS
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0571416A1

  公开（公告）日：1993-12-01
• POTENTIATION OF ANTIMICROBIAL EFFECTS
  申请人：BIOGLAN AB

  公开号：EP0636024B1

  公开（公告）日：1999-06-23